Biological progression of breast cancer and clinical implications

P. Vici, D. Sergi, L. Pizzuti, C. Vincenzoni, E. Baiocco, E. Mancini, M. Lopez, E. Vizza, L. D. Lauro

Research output: Contribution to journalArticlepeer-review


The classic view of tumor progression is that genetic mutation introduced in differentiated or progenitor cells causes tumors, through the acquisition of advantages for survival, and leading to phenotypic heterogeneity. Another theory (stem cell hypothesis) considers that tumor progression derives from cells within the tumor with stem cell characteristics of self-renewal and multiple differentiation potential. It is still unknown the timing of expression of various biological characteristics of breast cancer during the progression cascade, and the existence of clonal heterogeneity within primary tumor and synchronous or asynchronous distant metastases contributes to treatments failures.

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalClinica Terapeutica
Issue number4
Publication statusPublished - 2011


  • Biological progression
  • Breast cancer

ASJC Scopus subject areas

  • Medicine(all)


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