Biological role of vitamin C in keratinocytes

Maria Valeria Catani, Isabella Savini, Antonello Rossi, Gerry Melino, Luciana Avigliano

Research output: Contribution to journalArticlepeer-review


Epidemiological studies have suggested an association between vitamin C (and other antioxidant vitamins) and cancer risk. However, the mechanisms accounting for prevention have not been extensively investigated. In skin, vitamin C (ascorbic acid) exerts different biological roles, including photoprotective effects and participation in collagen synthesis. This paper reports new findings about additional functions of the vitamin. Vitamin C counteracts oxidative stress via transcriptional and post-translational mechanisms; this modulation may interfere with the activity of redox-sensitive transcription factors, commitment to differentiation or cell cycle arrest, and apoptosis in response to DNA damage. All of these vitamin C-mediated responses might be important in different cell types, allowing for the maintenance of body homeostasis.

Original languageEnglish
Pages (from-to)81-90
Number of pages10
JournalNutrition Reviews
Issue number3
Publication statusPublished - Mar 2005


  • Ascorbic acid AP-1
  • Keratinocytes
  • NF-kB
  • Oxidative stress
  • Vitamin C

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science


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