Abstract
Epidemiological studies have suggested an association between vitamin C (and other antioxidant vitamins) and cancer risk. However, the mechanisms accounting for prevention have not been extensively investigated. In skin, vitamin C (ascorbic acid) exerts different biological roles, including photoprotective effects and participation in collagen synthesis. This paper reports new findings about additional functions of the vitamin. Vitamin C counteracts oxidative stress via transcriptional and post-translational mechanisms; this modulation may interfere with the activity of redox-sensitive transcription factors, commitment to differentiation or cell cycle arrest, and apoptosis in response to DNA damage. All of these vitamin C-mediated responses might be important in different cell types, allowing for the maintenance of body homeostasis.
Original language | English |
---|---|
Pages (from-to) | 81-90 |
Number of pages | 10 |
Journal | Nutrition Reviews |
Volume | 63 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2005 |
Keywords
- Ascorbic acid AP-1
- Keratinocytes
- NF-kB
- Oxidative stress
- Vitamin C
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science