Biological roles of acid and neutral sphingomyelinases and their regulation by nitric oxide

Cristiana Perrotta; Emilio Clementi

doi:10.1152/physiol.00048.2009

Biological roles of acid and neutral sphingomyelinases and their regulation by nitric oxide

Cristiana Perrotta, Emilio Clementi

Istituto "Eugenio Medea" - Associazione La Nostra Famiglia

Research output: Contribution to journal › Article › peer-review

Abstract

Generation of the pleiotrope sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.

Original language	English
Pages (from-to)	64-71
Number of pages	8
Journal	Physiology
Volume	25
Issue number	2
DOIs	https://doi.org/10.1152/physiol.00048.2009
Publication status	Published - Apr 2010

ASJC Scopus subject areas

Physiology

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Biological roles of acid and neutral sphingomyelinases and their regulation by nitric oxide

Abstract

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