Abstract
Generation of the pleiotrope sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.
| Original language | English |
|---|---|
| Pages (from-to) | 64-71 |
| Number of pages | 8 |
| Journal | Physiology |
| Volume | 25 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2010 |
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ASJC Scopus subject areas
- Physiology
Cite this
Biological roles of acid and neutral sphingomyelinases and their regulation by nitric oxide. / Perrotta, Cristiana; Clementi, Emilio.
In: Physiology, Vol. 25, No. 2, 04.2010, p. 64-71.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biological roles of acid and neutral sphingomyelinases and their regulation by nitric oxide
AU - Perrotta, Cristiana
AU - Clementi, Emilio
PY - 2010/4
Y1 - 2010/4
N2 - Generation of the pleiotrope sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.
AB - Generation of the pleiotrope sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.
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UR - http://www.scopus.com/inward/citedby.url?scp=77951913548&partnerID=8YFLogxK
U2 - 10.1152/physiol.00048.2009
DO - 10.1152/physiol.00048.2009
M3 - Article
VL - 25
SP - 64
EP - 71
JO - Physiology
JF - Physiology
SN - 1548-9213
IS - 2
ER -