Biological roles of acid and neutral sphingomyelinases and their regulation by nitric oxide

Cristiana Perrotta, Emilio Clementi

Research output: Contribution to journalArticlepeer-review

Abstract

Generation of the pleiotrope sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.

Original languageEnglish
Pages (from-to)64-71
Number of pages8
JournalPhysiology
Volume25
Issue number2
DOIs
Publication statusPublished - Apr 2010

ASJC Scopus subject areas

  • Physiology

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