Abstract
Generation of the pleiotrope sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.
Original language | English |
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Pages (from-to) | 64-71 |
Number of pages | 8 |
Journal | Physiology |
Volume | 25 |
Issue number | 2 |
DOIs | |
Publication status | Published - Apr 2010 |
ASJC Scopus subject areas
- Physiology