TY - JOUR
T1 - Biologics in Children with Allergic Diseases
AU - Licari, Amelia
AU - Manti, Sara
AU - Marseglia, Alessia
AU - De Filippo, Maria
AU - De Sando, Elisabetta
AU - Foiadelli, Thomas
AU - Marseglia, Gian Luigi
PY - 2020
Y1 - 2020
N2 - The prevalence of allergic diseases has been remarkably increased in the last decades. The global health burden of these conditions is substantial, since patients may experience disability, anxiety and emotional distress, social restrictions, and reduced quality of life and productivity, in particular, in the most severe cases. Recent advances in understanding the pathophysiology of allergic disorders have allowed identifying novel therapeutic strategies for the treatment of severe and uncontrolled allergic diseases. Although most studies have been performed in allergic asthma, biological drugs targeting other allergic diseases such as chronic spontaneous urticaria, atopic dermatitis, and food allergy are showing promising results. In this review, the most recent evidence on biologic therapies for allergic diseases, focusing on the pediatric age has been presented.
AB - The prevalence of allergic diseases has been remarkably increased in the last decades. The global health burden of these conditions is substantial, since patients may experience disability, anxiety and emotional distress, social restrictions, and reduced quality of life and productivity, in particular, in the most severe cases. Recent advances in understanding the pathophysiology of allergic disorders have allowed identifying novel therapeutic strategies for the treatment of severe and uncontrolled allergic diseases. Although most studies have been performed in allergic asthma, biological drugs targeting other allergic diseases such as chronic spontaneous urticaria, atopic dermatitis, and food allergy are showing promising results. In this review, the most recent evidence on biologic therapies for allergic diseases, focusing on the pediatric age has been presented.
KW - Asthma
KW - atopic dermatitis
KW - biologics
KW - children
KW - chronic spontaneous urticaria
KW - food allergy.
UR - http://www.scopus.com/inward/record.url?scp=85088208698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088208698&partnerID=8YFLogxK
U2 - 10.2174/1573396315666191029123822
DO - 10.2174/1573396315666191029123822
M3 - Article
C2 - 31660839
AN - SCOPUS:85088208698
VL - 16
SP - 140
EP - 147
JO - Current Pediatric Reviews
JF - Current Pediatric Reviews
SN - 1573-3963
IS - 2
ER -