Biomarkers for physical frailty and sarcopenia: State of the science and future developments

Riccardo Calvani, Federico Marini, Matteo Cesari, Matteo Tosato, Stefan D. Anker, Stephan Von Haehling, Ram R. Miller, Roberto Bernabei, Francesco Landi, Emanuele Marzetti

Research output: Contribution to journalArticlepeer-review

Abstract

Physical frailty and sarcopenia are two common and largely overlapping geriatric conditions upstream of the disabling cascade. The lack of a unique operational definition for physical frailty and sarcopenia and the complex underlying pathophysiology make the development of biomarkers for these conditions extremely challenging. Indeed, the current definitional ambiguities of physical frailty and sarcopenia, together with their heterogeneous clinical manifestations, impact the accuracy, specificity, and sensitivity of individual biomarkers proposed so far. In this review, the current state of the art in the development of biomarkers for physical frailty and sarcopenia is presented. A novel approach for biomarker identification and validation is also introduced that moves from the ‘one fits all’ paradigm to a multivariate methodology.

Original languageEnglish
Pages (from-to)278-286
Number of pages9
JournalJournal of Cachexia, Sarcopenia and Muscle
Volume6
Issue number4
DOIs
Publication statusPublished - 2015

Keywords

  • Ageing
  • Circulating markers
  • Disability
  • Imaging
  • Multivariate modelling
  • Physical performance

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physiology (medical)

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