Biomarkers for predicting postmenopausal coronary heart disease

Research output: Contribution to journalArticle

Abstract

Coronary heart disease (CHD) is the main cause of death in post-menopausal women (PMW). Beyond the 'traditional cardiovascular risk factors of CHD, newer biomarkers, reflecting inflammation, endothelial function and oxidative stress, have received growing consideration. We systematically reviewed the literature on the biomarkers for predicting CHD in PMW. C-reactive protein, IL-6 and Lipoprotein (a) have been consistently found to be associated with CHD risk in PMW. However, no evidence supports the existence of a causal and independent link between such biomarkers and CHD in PMW. Also, the new biomarkers only marginally improve cardiovascular risk prediction. Upcoming studies are needed to provide further evidence on the validity of the new biomarkers in PMW and to understand their relationships with hormone therapy, opening new avenues for prevention.

Original languageEnglish
Pages (from-to)485-495
Number of pages11
JournalBiomarkers in Medicine
Volume5
Issue number4
DOIs
Publication statusPublished - Aug 2011

Keywords

  • atherosclerosis
  • biomarkers
  • coronary heart disease
  • dyslipidemia
  • hormone therapy
  • inflammation
  • menopause
  • oxidative stress

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

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