Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

Elena Antelmi, Fabio Pizza, Vincenzo Donadio, Marco Filardi, Yuri L Sosero, Alex Incensi, Stefano Vandi, Monica Moresco, Raffaele Ferri, Sara Marelli, Luigi Ferini-Strambi, Rocco Liguori, Giuseppe Plazzi

Research output: Contribution to journalArticlepeer-review


To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.

Original languageEnglish
Pages (from-to)1872-1876
Number of pages5
JournalAnnals of Clinical and Translational Neurology
Issue number9
Publication statusPublished - Sep 2019


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