Abstract
To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.
| Original language | English |
|---|---|
| Pages (from-to) | 1872-1876 |
| Number of pages | 5 |
| Journal | Annals of Clinical and Translational Neurology |
| Volume | 6 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2019 |
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Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients. / Antelmi, Elena; Pizza, Fabio; Donadio, Vincenzo; Filardi, Marco; Sosero, Yuri L; Incensi, Alex; Vandi, Stefano; Moresco, Monica; Ferri, Raffaele; Marelli, Sara; Ferini-Strambi, Luigi; Liguori, Rocco; Plazzi, Giuseppe.
In: Annals of Clinical and Translational Neurology, Vol. 6, No. 9, 09.2019, p. 1872-1876.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients
AU - Antelmi, Elena
AU - Pizza, Fabio
AU - Donadio, Vincenzo
AU - Filardi, Marco
AU - Sosero, Yuri L
AU - Incensi, Alex
AU - Vandi, Stefano
AU - Moresco, Monica
AU - Ferri, Raffaele
AU - Marelli, Sara
AU - Ferini-Strambi, Luigi
AU - Liguori, Rocco
AU - Plazzi, Giuseppe
N1 - Ricercatori distaccati presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Antelmi Elena, Pizza Fabio, Vandi Stefano, Liguori Rocco, Plazzi Giuseppe). Richiesto "CORRIGENDUM" per modifica di affiliazione (inserito nel pdf della pubblicazione qui allegato).
PY - 2019/9
Y1 - 2019/9
N2 - To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.
AB - To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.
U2 - 10.1002/acn3.50833
DO - 10.1002/acn3.50833
M3 - Article
C2 - 31386270
VL - 6
SP - 1872
EP - 1876
JO - Annals of Clinical and Translational Neurology
JF - Annals of Clinical and Translational Neurology
SN - 2328-9503
IS - 9
ER -