Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

Elena Antelmi, Fabio Pizza, Vincenzo Donadio, Marco Filardi, Yuri L Sosero, Alex Incensi, Stefano Vandi, Monica Moresco, Raffaele Ferri, Sara Marelli, Luigi Ferini-Strambi, Rocco Liguori, Giuseppe Plazzi

Research output: Contribution to journalArticle

Abstract

To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.

Original languageEnglish
Pages (from-to)1872-1876
Number of pages5
JournalAnnals of Clinical and Translational Neurology
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 2019

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REM Sleep Behavior Disorder
Synucleins
Biomarkers
Biopsy
Narcolepsy
Skin
Polysomnography

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Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients. / Antelmi, Elena; Pizza, Fabio; Donadio, Vincenzo; Filardi, Marco; Sosero, Yuri L; Incensi, Alex; Vandi, Stefano; Moresco, Monica; Ferri, Raffaele; Marelli, Sara; Ferini-Strambi, Luigi; Liguori, Rocco; Plazzi, Giuseppe.

In: Annals of Clinical and Translational Neurology, Vol. 6, No. 9, 09.2019, p. 1872-1876.

Research output: Contribution to journalArticle

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AU - Incensi, Alex

AU - Vandi, Stefano

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