Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

Elena Antelmi; Fabio Pizza; Vincenzo Donadio; Marco Filardi; Yuri L Sosero; Alex Incensi; Stefano Vandi; Monica Moresco; Raffaele Ferri; Sara Marelli; Luigi Ferini-Strambi; Rocco Liguori; Giuseppe Plazzi

doi:10.1002/acn3.50833

Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

Elena Antelmi, Fabio Pizza, Vincenzo Donadio, Marco Filardi, Yuri L Sosero, Alex Incensi, Stefano Vandi, Monica Moresco, Raffaele Ferri, Sara Marelli, Luigi Ferini-Strambi, Rocco Liguori, Giuseppe Plazzi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article

Abstract

To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.

Original language	English
Pages (from-to)	1872-1876
Number of pages	5
Journal	Annals of Clinical and Translational Neurology
Volume	6
Issue number	9
DOIs	https://doi.org/10.1002/acn3.50833
Publication status	Published - Sep 2019

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Antelmi, E., Pizza, F., Donadio, V., Filardi, M., Sosero, Y. L., Incensi, A., Vandi, S., Moresco, M., Ferri, R., Marelli, S., Ferini-Strambi, L., Liguori, R., & Plazzi, G. (2019). Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients. Annals of Clinical and Translational Neurology, 6(9), 1872-1876. https://doi.org/10.1002/acn3.50833

Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients. / Antelmi, Elena ; Pizza, Fabio ; Donadio, Vincenzo; Filardi, Marco; Sosero, Yuri L; Incensi, Alex ; Vandi, Stefano; Moresco, Monica; Ferri, Raffaele; Marelli, Sara; Ferini-Strambi, Luigi; Liguori, Rocco ; Plazzi, Giuseppe.

In: Annals of Clinical and Translational Neurology, Vol. 6, No. 9, 09.2019, p. 1872-1876.

Research output: Contribution to journal › Article

Antelmi, Elena ; Pizza, Fabio ; Donadio, Vincenzo ; Filardi, Marco ; Sosero, Yuri L ; Incensi, Alex ; Vandi, Stefano ; Moresco, Monica ; Ferri, Raffaele ; Marelli, Sara ; Ferini-Strambi, Luigi ; Liguori, Rocco ; Plazzi, Giuseppe. / Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients. In: Annals of Clinical and Translational Neurology. 2019 ; Vol. 6, No. 9. pp. 1872-1876.

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title = "Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients",

abstract = "To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.",

author = "Elena Antelmi and Fabio Pizza and Vincenzo Donadio and Marco Filardi and Sosero, {Yuri L} and Alex Incensi and Stefano Vandi and Monica Moresco and Raffaele Ferri and Sara Marelli and Luigi Ferini-Strambi and Rocco Liguori and Giuseppe Plazzi",

note = "Ricercatori distaccati presso IRCCS a seguito Convenzione esclusiva con Universit{\`a} di Bologna (Antelmi Elena, Pizza Fabio, Vandi Stefano, Liguori Rocco, Plazzi Giuseppe). Richiesto {"}CORRIGENDUM{"} per modifica di affiliazione (inserito nel pdf della pubblicazione qui allegato). ",

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AU - Antelmi, Elena

AU - Pizza, Fabio

AU - Donadio, Vincenzo

AU - Filardi, Marco

AU - Sosero, Yuri L

AU - Incensi, Alex

AU - Vandi, Stefano

AU - Moresco, Monica

AU - Ferri, Raffaele

AU - Marelli, Sara

AU - Ferini-Strambi, Luigi

AU - Liguori, Rocco

AU - Plazzi, Giuseppe

N1 - Ricercatori distaccati presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Antelmi Elena, Pizza Fabio, Vandi Stefano, Liguori Rocco, Plazzi Giuseppe). Richiesto "CORRIGENDUM" per modifica di affiliazione (inserito nel pdf della pubblicazione qui allegato).

PY - 2019/9

Y1 - 2019/9

N2 - To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.

AB - To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.

U2 - 10.1002/acn3.50833

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JO - Annals of Clinical and Translational Neurology

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Istituto Scienze Neurologiche - EPILESSIA, MALATTIE DEL SONNO E DEI BIORITMI, SISTEMA NEUROENDOCRINO

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Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients

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Istituto Scienze Neurologiche - EPILESSIA, MALATTIE DEL SONNO E DEI BIORITMI, SISTEMA NEUROENDOCRINO