Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 119-131 |
| Number of pages | 13 |
| Journal | Neurobiology of Aging |
| Volume | 52 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2017 |
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Biomarkers for the diagnosis of Alzheimer's disease in clinical practice: an Italian intersocietal roadmap. / Frisoni, GB; Perani, D; Bastianello, S; Bernardi, G; Porteri, C; Boccardi, M; Cappa, SF; Trabucchi, Marco; Padovani, Alessandro.
In: Neurobiology of Aging, Vol. 52, No. 4, 2017, p. 119-131.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Biomarkers for the diagnosis of Alzheimer's disease in clinical practice: an Italian intersocietal roadmap
AU - Frisoni, GB
AU - Perani, D
AU - Bastianello, S
AU - Bernardi, G
AU - Porteri, C
AU - Boccardi, M
AU - Cappa, SF
AU - Trabucchi, Marco
AU - Padovani, Alessandro
PY - 2017
Y1 - 2017
N2 - Biomarkers of brain amyloidosis and neurodegeneration/synaptic dysfunction are featured in recent diagnostic criteria for Alzheimer's disease. Several gaps in our knowledge, however, need to be filled before they can be adopted clinically. The aim of this article is to describe a roadmap, developed by a multidisciplinary task force, to rationally implement biomarkers for Italian Memory Clinics. This roadmap is based on a framework comprising 5 sequential phases: identification of leads for potentially useful biomarkers; development of clinical assays for clinical disease; evaluation of detection of early stages; definition of operating characteristics in relevant populations; and estimation of reducing disease-associated mortality, morbidity, and disability. The roadmap was devised by identifying current evidence of validity, still missing evidence, and action needed to collect this missing evidence. With appropriate adaptation to local, country-specific circumstances, the roadmap can be translated to other countries. © 2016 Elsevier Inc.
AB - Biomarkers of brain amyloidosis and neurodegeneration/synaptic dysfunction are featured in recent diagnostic criteria for Alzheimer's disease. Several gaps in our knowledge, however, need to be filled before they can be adopted clinically. The aim of this article is to describe a roadmap, developed by a multidisciplinary task force, to rationally implement biomarkers for Italian Memory Clinics. This roadmap is based on a framework comprising 5 sequential phases: identification of leads for potentially useful biomarkers; development of clinical assays for clinical disease; evaluation of detection of early stages; definition of operating characteristics in relevant populations; and estimation of reducing disease-associated mortality, morbidity, and disability. The roadmap was devised by identifying current evidence of validity, still missing evidence, and action needed to collect this missing evidence. With appropriate adaptation to local, country-specific circumstances, the roadmap can be translated to other countries. © 2016 Elsevier Inc.
U2 - 10.1016/j.neurobiolaging.2016.02.033
DO - 10.1016/j.neurobiolaging.2016.02.033
M3 - Article
VL - 52
SP - 119
EP - 131
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 4
ER -