Biomarkers for the diagnosis of Alzheimer's disease in clinical practice: an Italian intersocietal roadmap

G.B. Frisoni, D. Perani, S. Bastianello, G. Bernardi, C. Porteri, M. Boccardi, S.F. Cappa, M. Trabucchi, A. Padovani

Research output: Contribution to journalArticlepeer-review


Biomarkers of brain amyloidosis and neurodegeneration/synaptic dysfunction are featured in recent diagnostic criteria for Alzheimer's disease. Several gaps in our knowledge, however, need to be filled before they can be adopted clinically. The aim of this article is to describe a roadmap, developed by a multidisciplinary task force, to rationally implement biomarkers for Italian Memory Clinics. This roadmap is based on a framework comprising 5 sequential phases: identification of leads for potentially useful biomarkers; development of clinical assays for clinical disease; evaluation of detection of early stages; definition of operating characteristics in relevant populations; and estimation of reducing disease-associated mortality, morbidity, and disability. The roadmap was devised by identifying current evidence of validity, still missing evidence, and action needed to collect this missing evidence. With appropriate adaptation to local, country-specific circumstances, the roadmap can be translated to other countries. © 2016 Elsevier Inc.
Original languageEnglish
Pages (from-to)119-131
Number of pages13
JournalNeurobiology of Aging
Publication statusPublished - 2017


  • Alzheimer
  • Biomarkers
  • Diagnosis
  • Validation
  • biological marker
  • tau protein
  • amyloid beta protein
  • amyloid beta-protein (1-42)
  • peptide fragment
  • Alzheimer disease
  • Article
  • brain atrophy
  • cerebrospinal fluid analysis
  • clinical practice
  • comorbidity
  • cost benefit analysis
  • diagnostic accuracy
  • differential diagnosis
  • disability
  • disease association
  • hippocampus
  • human
  • ligand binding
  • mortality
  • neuropsychological test
  • prognosis
  • protein expression
  • cerebrospinal fluid
  • diagnostic imaging
  • diffusion weighted imaging
  • Italy
  • positron emission tomography
  • single photon emission computed tomography
  • Alzheimer Disease
  • Amyloid beta-Peptides
  • Diffusion Magnetic Resonance Imaging
  • Humans
  • Peptide Fragments
  • Positron-Emission Tomography
  • tau Proteins
  • Tomography, Emission-Computed, Single-Photon


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