Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood

Rosa Luciano, Gloria Maria Barraco, Maurizio Muraca, Simonetta Ottino, Maria Rita Spreghini, Rita Wietrzykowska Sforza, Carmela Rustico, Giuseppe Stefano Morino, Melania Manco

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To answer the question of whether onset of insulin resistance (IR) early in life enhances the risk of developing dementia and Alzheimer disease (AD), serum levels of 2 molecules that are likely associated with development of AD, the amyloid β-protein 42 (Aβ42) and presenilin 1 (PSEN1), were estimated in 101 preschoolers and 309 adolescents of various BMI. METHODS: Participants (215 boys; 48.8%) were normal weight (n = 176; 40%), overweight (n = 135; 30.7%), and obese (n = 129; 29.3%). The HOmeostasis Model of IR (HOMA-IR), HOMA percent β-cell function (HOMA-β) and QUantitative Insulin-sensitivity Check Index (QUICKI) were calculated. RESULTS: Obese adolescents had values of Aβ42 higher than overweight and normal-weight peers (190.2 ± 9.16 vs 125.9 ± 7.38 vs 129.5 ± 7.65 pg/mL; P <.0001) as well as higher levels of PSEN1 (2.34 ± 0.20 vs 1.95 ± 0.20 vs 1.65 ± 0.26 ng/mL; P <.0001). Concentrations of Aβ42 were significantly correlated with BMI (ρ = 0.262; P <.0001), HOMA-IR (ρ = 0.261; P <.0001) and QUICKI (ρ = -0.220; P <.0001). PSEN1 levels were correlated with BMI (ρ = 0.248; P <.0001), HOMA-IR (ρ = 0.242; P <.0001), and QUICKI (ρ = -0.256; P <.0001). Western blot analysis confirmed that PSEN1 assays measured the full-length protein. CONCLUSION: Obese adolescents with IR present higher levels of circulating molecules that might be associated with increased risk of developing later in elderly cognitive impairment, dementia, and AD.

Original languageEnglish
Pages (from-to)1074-1081
Number of pages8
JournalPediatrics
Volume135
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

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Disease Resistance
Pediatric Obesity
Presenilin-1
Insulin Resistance
Alzheimer Disease
Biomarkers
Amyloidogenic Proteins
Homeostasis
Dementia
Weights and Measures
Western Blotting
Serum
Proteins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Luciano, R., Barraco, G. M., Muraca, M., Ottino, S., Spreghini, M. R., Sforza, R. W., ... Manco, M. (2015). Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood. Pediatrics, 135(6), 1074-1081. https://doi.org/10.1542/peds.2014-2391

Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood. / Luciano, Rosa; Barraco, Gloria Maria; Muraca, Maurizio; Ottino, Simonetta; Spreghini, Maria Rita; Sforza, Rita Wietrzykowska; Rustico, Carmela; Morino, Giuseppe Stefano; Manco, Melania.

In: Pediatrics, Vol. 135, No. 6, 01.06.2015, p. 1074-1081.

Research output: Contribution to journalArticle

Luciano, R, Barraco, GM, Muraca, M, Ottino, S, Spreghini, MR, Sforza, RW, Rustico, C, Morino, GS & Manco, M 2015, 'Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood', Pediatrics, vol. 135, no. 6, pp. 1074-1081. https://doi.org/10.1542/peds.2014-2391
Luciano R, Barraco GM, Muraca M, Ottino S, Spreghini MR, Sforza RW et al. Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood. Pediatrics. 2015 Jun 1;135(6):1074-1081. https://doi.org/10.1542/peds.2014-2391
Luciano, Rosa ; Barraco, Gloria Maria ; Muraca, Maurizio ; Ottino, Simonetta ; Spreghini, Maria Rita ; Sforza, Rita Wietrzykowska ; Rustico, Carmela ; Morino, Giuseppe Stefano ; Manco, Melania. / Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood. In: Pediatrics. 2015 ; Vol. 135, No. 6. pp. 1074-1081.
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abstract = "OBJECTIVE: To answer the question of whether onset of insulin resistance (IR) early in life enhances the risk of developing dementia and Alzheimer disease (AD), serum levels of 2 molecules that are likely associated with development of AD, the amyloid β-protein 42 (Aβ42) and presenilin 1 (PSEN1), were estimated in 101 preschoolers and 309 adolescents of various BMI. METHODS: Participants (215 boys; 48.8{\%}) were normal weight (n = 176; 40{\%}), overweight (n = 135; 30.7{\%}), and obese (n = 129; 29.3{\%}). The HOmeostasis Model of IR (HOMA-IR), HOMA percent β-cell function (HOMA-β) and QUantitative Insulin-sensitivity Check Index (QUICKI) were calculated. RESULTS: Obese adolescents had values of Aβ42 higher than overweight and normal-weight peers (190.2 ± 9.16 vs 125.9 ± 7.38 vs 129.5 ± 7.65 pg/mL; P <.0001) as well as higher levels of PSEN1 (2.34 ± 0.20 vs 1.95 ± 0.20 vs 1.65 ± 0.26 ng/mL; P <.0001). Concentrations of Aβ42 were significantly correlated with BMI (ρ = 0.262; P <.0001), HOMA-IR (ρ = 0.261; P <.0001) and QUICKI (ρ = -0.220; P <.0001). PSEN1 levels were correlated with BMI (ρ = 0.248; P <.0001), HOMA-IR (ρ = 0.242; P <.0001), and QUICKI (ρ = -0.256; P <.0001). Western blot analysis confirmed that PSEN1 assays measured the full-length protein. CONCLUSION: Obese adolescents with IR present higher levels of circulating molecules that might be associated with increased risk of developing later in elderly cognitive impairment, dementia, and AD.",
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AU - Luciano, Rosa

AU - Barraco, Gloria Maria

AU - Muraca, Maurizio

AU - Ottino, Simonetta

AU - Spreghini, Maria Rita

AU - Sforza, Rita Wietrzykowska

AU - Rustico, Carmela

AU - Morino, Giuseppe Stefano

AU - Manco, Melania

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N2 - OBJECTIVE: To answer the question of whether onset of insulin resistance (IR) early in life enhances the risk of developing dementia and Alzheimer disease (AD), serum levels of 2 molecules that are likely associated with development of AD, the amyloid β-protein 42 (Aβ42) and presenilin 1 (PSEN1), were estimated in 101 preschoolers and 309 adolescents of various BMI. METHODS: Participants (215 boys; 48.8%) were normal weight (n = 176; 40%), overweight (n = 135; 30.7%), and obese (n = 129; 29.3%). The HOmeostasis Model of IR (HOMA-IR), HOMA percent β-cell function (HOMA-β) and QUantitative Insulin-sensitivity Check Index (QUICKI) were calculated. RESULTS: Obese adolescents had values of Aβ42 higher than overweight and normal-weight peers (190.2 ± 9.16 vs 125.9 ± 7.38 vs 129.5 ± 7.65 pg/mL; P <.0001) as well as higher levels of PSEN1 (2.34 ± 0.20 vs 1.95 ± 0.20 vs 1.65 ± 0.26 ng/mL; P <.0001). Concentrations of Aβ42 were significantly correlated with BMI (ρ = 0.262; P <.0001), HOMA-IR (ρ = 0.261; P <.0001) and QUICKI (ρ = -0.220; P <.0001). PSEN1 levels were correlated with BMI (ρ = 0.248; P <.0001), HOMA-IR (ρ = 0.242; P <.0001), and QUICKI (ρ = -0.256; P <.0001). Western blot analysis confirmed that PSEN1 assays measured the full-length protein. CONCLUSION: Obese adolescents with IR present higher levels of circulating molecules that might be associated with increased risk of developing later in elderly cognitive impairment, dementia, and AD.

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