Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene

Seymour Garte, Todor Popov, Tzveta Georgieva, Claudia Bolognesi, Emanuela Taioli, PierAlberto Bertazzi, Peter Farmer, Domenico Franco Merlo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Biomarkers of benzene exposure and effect were evaluated in 158 Bulgarian petrochemical workers and 50 matched controls. Air exposures to benzene averaged about 1.8 ppm, for workers and 0.02 ppm for controls. Urinary trans,trans-muconic acid, and S-phenylmuconic acid, showed dose response relationships with benzene air exposure. The dose response curve for DNA single strand breaks (SSB), but not for the metabolites, showed a saturation effect. NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene.

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalChemico-Biological Interactions
Volume153-154
DOIs
Publication statusPublished - May 30 2005

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Biomarkers
Benzene
Petrochemicals
Metabolites
Air
Single-Stranded DNA Breaks
Genotype
Acids
DNA

Keywords

  • Benzene
  • Biomarkers
  • DNA single strand breaks
  • NQO1 genotype
  • Petrochemical workers

ASJC Scopus subject areas

  • Toxicology

Cite this

Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene. / Garte, Seymour; Popov, Todor; Georgieva, Tzveta; Bolognesi, Claudia; Taioli, Emanuela; Bertazzi, PierAlberto; Farmer, Peter; Merlo, Domenico Franco.

In: Chemico-Biological Interactions, Vol. 153-154, 30.05.2005, p. 247-251.

Research output: Contribution to journalArticle

Garte, Seymour ; Popov, Todor ; Georgieva, Tzveta ; Bolognesi, Claudia ; Taioli, Emanuela ; Bertazzi, PierAlberto ; Farmer, Peter ; Merlo, Domenico Franco. / Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene. In: Chemico-Biological Interactions. 2005 ; Vol. 153-154. pp. 247-251.
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