Biomarkers of exposure and effect in Bulgarian petrochemical workers exposed to benzene

Seymour Garte, Todor Popov, Tzveta Georgieva, Claudia Bolognesi, Emanuela Taioli, PierAlberto Bertazzi, Peter Farmer, Domenico Franco Merlo

Research output: Contribution to journalArticlepeer-review


Biomarkers of benzene exposure and effect were evaluated in 158 Bulgarian petrochemical workers and 50 matched controls. Air exposures to benzene averaged about 1.8 ppm, for workers and 0.02 ppm for controls. Urinary trans,trans-muconic acid, and S-phenylmuconic acid, showed dose response relationships with benzene air exposure. The dose response curve for DNA single strand breaks (SSB), but not for the metabolites, showed a saturation effect. NQO1 genotype had a significant effect on SSB. We conclude that the pathways for these metabolites may be distinct from those involved in some forms of genotoxic damage induced by benzene.

Original languageEnglish
Pages (from-to)247-251
Number of pages5
JournalChemico-Biological Interactions
Publication statusPublished - May 30 2005


  • Benzene
  • Biomarkers
  • DNA single strand breaks
  • NQO1 genotype
  • Petrochemical workers

ASJC Scopus subject areas

  • Toxicology


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