Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort

M. Matejcic, J. de Batlle, C. Ricci, C. Biessy, F. Perrier, I. Huybrechts, E. Weiderpass, M. C. Boutron-Ruault, C. Cadeau, M. His, D. G. Cox, H. Boeing, R. T. Fortner, R. Kaaks, P. Lagiou, A. Trichopoulou, V. Benetou, R. Tumino, S. Panico, S. SieriD. Palli, F. Ricceri, H. Bas Bueno-de-Mesquita, G. Skeie, P. Amiano, M. J. Sánchez, M. D. Chirlaque, A. Barricarte, J. R. Quirós, G. Buckland, C. H. van Gils, P. H. Peeters, T. J. Key, E. Riboli, B. Gylling, A. Zeleniuch-Jacquotte, M. J. Gunter, I. Romieu, V. Chajès

Research output: Contribution to journalArticle

Abstract

Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (ORQ4-Q1 = 1.26; 95% CI 1.00–1.58; Ptrend = 0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (ORQ4-Q1 = 1.29; 95% CI 1.02–1.62; Ptrend = 0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation.

Original languageEnglish
Pages (from-to)1246-1259
Number of pages14
JournalInternational Journal of Cancer
Volume140
Issue number6
DOIs
Publication statusPublished - Mar 15 2017

Fingerprint

Vitamin B 12
Folic Acid
Biomarkers
Breast Neoplasms
Neoplasms
Vitamin B Complex
Alcohols
Logistic Models
Hormones
Progesterone Receptors
Estrogen Receptors
Epidemiologic Studies
Cohort Studies
Odds Ratio
Prospective Studies

Keywords

  • alcohol
  • breast cancer
  • folate
  • hormone receptor status
  • MTHFR polymorphism
  • plasma biomarkers
  • vitamin B12

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Matejcic, M., de Batlle, J., Ricci, C., Biessy, C., Perrier, F., Huybrechts, I., ... Chajès, V. (2017). Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort. International Journal of Cancer, 140(6), 1246-1259. https://doi.org/10.1002/ijc.30536

Biomarkers of folate and vitamin B12 and breast cancer risk : report from the EPIC cohort. / Matejcic, M.; de Batlle, J.; Ricci, C.; Biessy, C.; Perrier, F.; Huybrechts, I.; Weiderpass, E.; Boutron-Ruault, M. C.; Cadeau, C.; His, M.; Cox, D. G.; Boeing, H.; Fortner, R. T.; Kaaks, R.; Lagiou, P.; Trichopoulou, A.; Benetou, V.; Tumino, R.; Panico, S.; Sieri, S.; Palli, D.; Ricceri, F.; Bueno-de-Mesquita, H. Bas; Skeie, G.; Amiano, P.; Sánchez, M. J.; Chirlaque, M. D.; Barricarte, A.; Quirós, J. R.; Buckland, G.; van Gils, C. H.; Peeters, P. H.; Key, T. J.; Riboli, E.; Gylling, B.; Zeleniuch-Jacquotte, A.; Gunter, M. J.; Romieu, I.; Chajès, V.

In: International Journal of Cancer, Vol. 140, No. 6, 15.03.2017, p. 1246-1259.

Research output: Contribution to journalArticle

Matejcic, M, de Batlle, J, Ricci, C, Biessy, C, Perrier, F, Huybrechts, I, Weiderpass, E, Boutron-Ruault, MC, Cadeau, C, His, M, Cox, DG, Boeing, H, Fortner, RT, Kaaks, R, Lagiou, P, Trichopoulou, A, Benetou, V, Tumino, R, Panico, S, Sieri, S, Palli, D, Ricceri, F, Bueno-de-Mesquita, HB, Skeie, G, Amiano, P, Sánchez, MJ, Chirlaque, MD, Barricarte, A, Quirós, JR, Buckland, G, van Gils, CH, Peeters, PH, Key, TJ, Riboli, E, Gylling, B, Zeleniuch-Jacquotte, A, Gunter, MJ, Romieu, I & Chajès, V 2017, 'Biomarkers of folate and vitamin B12 and breast cancer risk: report from the EPIC cohort', International Journal of Cancer, vol. 140, no. 6, pp. 1246-1259. https://doi.org/10.1002/ijc.30536
Matejcic, M. ; de Batlle, J. ; Ricci, C. ; Biessy, C. ; Perrier, F. ; Huybrechts, I. ; Weiderpass, E. ; Boutron-Ruault, M. C. ; Cadeau, C. ; His, M. ; Cox, D. G. ; Boeing, H. ; Fortner, R. T. ; Kaaks, R. ; Lagiou, P. ; Trichopoulou, A. ; Benetou, V. ; Tumino, R. ; Panico, S. ; Sieri, S. ; Palli, D. ; Ricceri, F. ; Bueno-de-Mesquita, H. Bas ; Skeie, G. ; Amiano, P. ; Sánchez, M. J. ; Chirlaque, M. D. ; Barricarte, A. ; Quirós, J. R. ; Buckland, G. ; van Gils, C. H. ; Peeters, P. H. ; Key, T. J. ; Riboli, E. ; Gylling, B. ; Zeleniuch-Jacquotte, A. ; Gunter, M. J. ; Romieu, I. ; Chajès, V. / Biomarkers of folate and vitamin B12 and breast cancer risk : report from the EPIC cohort. In: International Journal of Cancer. 2017 ; Vol. 140, No. 6. pp. 1246-1259.
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AU - Perrier, F.

AU - Huybrechts, I.

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AU - Cadeau, C.

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AU - Cox, D. G.

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AU - Fortner, R. T.

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AU - Lagiou, P.

AU - Trichopoulou, A.

AU - Benetou, V.

AU - Tumino, R.

AU - Panico, S.

AU - Sieri, S.

AU - Palli, D.

AU - Ricceri, F.

AU - Bueno-de-Mesquita, H. Bas

AU - Skeie, G.

AU - Amiano, P.

AU - Sánchez, M. J.

AU - Chirlaque, M. D.

AU - Barricarte, A.

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AU - Buckland, G.

AU - van Gils, C. H.

AU - Peeters, P. H.

AU - Key, T. J.

AU - Riboli, E.

AU - Gylling, B.

AU - Zeleniuch-Jacquotte, A.

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AU - Romieu, I.

AU - Chajès, V.

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KW - hormone receptor status

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