Biomarkers of good EULAR response to the B cell depletion therapy in all seropositive rheumatoid arthritis patients: Clues for the pathogenesis

Gianfranco Ferraccioli; Barbara Tolusso; Francesca Bobbio-Pallavicini; Elisa Gremese; Viviana Ravagnani; Maurizio Benucci; Edoardo Podestà; Fabiola Atzeni; Alice Mannocci; Domenico Biasi; Mariangela Manfredi; Piercarlo Sarzi-Puttini; Bruno Laganà; Carlomaurizio Montecucco

doi:10.1371/journal.pone.0040362

Biomarkers of good EULAR response to the B cell depletion therapy in all seropositive rheumatoid arthritis patients: Clues for the pathogenesis

Gianfranco Ferraccioli, Barbara Tolusso, Francesca Bobbio-Pallavicini, Elisa Gremese, Viviana Ravagnani, Maurizio Benucci, Edoardo Podestà, Fabiola Atzeni, Alice Mannocci, Domenico Biasi, Mariangela Manfredi, Piercarlo Sarzi-Puttini, Bruno Laganà, Carlomaurizio Montecucco

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To find out whether a high number of auto-antibodies can increase the probability of a "good-EULAR response" and to identify the possible biomarkers of response in seropositive rheumatoid arthritis (RA) patients undergoing the B cell depletion therapy (BCDT). Patients and Methods: One hundred and thirty-eight patients with long standing RA (LSRA), 75% non or poorly responsive to one or more TNFα blockers, all seropositive for at least one autoantibody (AAB) (RF-IgM, RF-IgA, RF-IgG, anti-MCV, ACPA-IgG, ACPA-IgA, ACPA-IgM) received one full course of BCDT. The major outcomes (moderate or good-EULAR response) were assessed after 6 months of therapy. The IL6 and BAFF levels were also determined. Results: At a 6-month follow-up, 33 (23.9%) of the RA patients achieved a good EULAR response. Having up to 5-AABs positivity increased the chances for treatment response. After a logistic regression analysis, however, only 4 baseline factors arose as associated with a good-EULAR response: no steroid therapy (OR = 6.25), a lymphocyte count 52.1 IU/ml (OR = 8.37) and BAFF levels

Original language	English
Article number	e40362
Journal	PLoS One
Volume	7
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0040362
Publication status	Published - Jul 30 2012

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Ferraccioli, G., Tolusso, B., Bobbio-Pallavicini, F., Gremese, E., Ravagnani, V., Benucci, M., Podestà, E., Atzeni, F., Mannocci, A., Biasi, D., Manfredi, M., Sarzi-Puttini, P., Laganà, B., & Montecucco, C. (2012). Biomarkers of good EULAR response to the B cell depletion therapy in all seropositive rheumatoid arthritis patients: Clues for the pathogenesis. PLoS One, 7(7), [e40362]. https://doi.org/10.1371/journal.pone.0040362

Ferraccioli, G, Tolusso, B, Bobbio-Pallavicini, F, Gremese, E, Ravagnani, V, Benucci, M, Podestà, E, Atzeni, F, Mannocci, A, Biasi, D, Manfredi, M, Sarzi-Puttini, P, Laganà, B & Montecucco, C 2012, 'Biomarkers of good EULAR response to the B cell depletion therapy in all seropositive rheumatoid arthritis patients: Clues for the pathogenesis', PLoS One, vol. 7, no. 7, e40362. https://doi.org/10.1371/journal.pone.0040362

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abstract = "Objective: To find out whether a high number of auto-antibodies can increase the probability of a {"}good-EULAR response{"} and to identify the possible biomarkers of response in seropositive rheumatoid arthritis (RA) patients undergoing the B cell depletion therapy (BCDT). Patients and Methods: One hundred and thirty-eight patients with long standing RA (LSRA), 75% non or poorly responsive to one or more TNFα blockers, all seropositive for at least one autoantibody (AAB) (RF-IgM, RF-IgA, RF-IgG, anti-MCV, ACPA-IgG, ACPA-IgA, ACPA-IgM) received one full course of BCDT. The major outcomes (moderate or good-EULAR response) were assessed after 6 months of therapy. The IL6 and BAFF levels were also determined. Results: At a 6-month follow-up, 33 (23.9%) of the RA patients achieved a good EULAR response. Having up to 5-AABs positivity increased the chances for treatment response. After a logistic regression analysis, however, only 4 baseline factors arose as associated with a good-EULAR response: no steroid therapy (OR = 6.25), a lymphocyte count 52.1 IU/ml (OR = 8.37) and BAFF levels ",

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T2 - Clues for the pathogenesis

AU - Ferraccioli, Gianfranco

AU - Tolusso, Barbara

AU - Bobbio-Pallavicini, Francesca

AU - Gremese, Elisa

AU - Ravagnani, Viviana

AU - Benucci, Maurizio

AU - Podestà, Edoardo

AU - Atzeni, Fabiola

AU - Mannocci, Alice

AU - Biasi, Domenico

AU - Manfredi, Mariangela

AU - Sarzi-Puttini, Piercarlo

AU - Laganà, Bruno

AU - Montecucco, Carlomaurizio

PY - 2012/7/30

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N2 - Objective: To find out whether a high number of auto-antibodies can increase the probability of a "good-EULAR response" and to identify the possible biomarkers of response in seropositive rheumatoid arthritis (RA) patients undergoing the B cell depletion therapy (BCDT). Patients and Methods: One hundred and thirty-eight patients with long standing RA (LSRA), 75% non or poorly responsive to one or more TNFα blockers, all seropositive for at least one autoantibody (AAB) (RF-IgM, RF-IgA, RF-IgG, anti-MCV, ACPA-IgG, ACPA-IgA, ACPA-IgM) received one full course of BCDT. The major outcomes (moderate or good-EULAR response) were assessed after 6 months of therapy. The IL6 and BAFF levels were also determined. Results: At a 6-month follow-up, 33 (23.9%) of the RA patients achieved a good EULAR response. Having up to 5-AABs positivity increased the chances for treatment response. After a logistic regression analysis, however, only 4 baseline factors arose as associated with a good-EULAR response: no steroid therapy (OR = 6.25), a lymphocyte count 52.1 IU/ml (OR = 8.37) and BAFF levels

AB - Objective: To find out whether a high number of auto-antibodies can increase the probability of a "good-EULAR response" and to identify the possible biomarkers of response in seropositive rheumatoid arthritis (RA) patients undergoing the B cell depletion therapy (BCDT). Patients and Methods: One hundred and thirty-eight patients with long standing RA (LSRA), 75% non or poorly responsive to one or more TNFα blockers, all seropositive for at least one autoantibody (AAB) (RF-IgM, RF-IgA, RF-IgG, anti-MCV, ACPA-IgG, ACPA-IgA, ACPA-IgM) received one full course of BCDT. The major outcomes (moderate or good-EULAR response) were assessed after 6 months of therapy. The IL6 and BAFF levels were also determined. Results: At a 6-month follow-up, 33 (23.9%) of the RA patients achieved a good EULAR response. Having up to 5-AABs positivity increased the chances for treatment response. After a logistic regression analysis, however, only 4 baseline factors arose as associated with a good-EULAR response: no steroid therapy (OR = 6.25), a lymphocyte count 52.1 IU/ml (OR = 8.37) and BAFF levels

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Biomarkers of good EULAR response to the B cell depletion therapy in all seropositive rheumatoid arthritis patients: Clues for the pathogenesis

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