Biomarkers of inflammation and breast cancer risk

A case-control study nested in the EPIC-Varese cohort

Claudia Agnoli, Sara Grioni, Valeria Pala, Alessandra Allione, Giuseppe Matullo, Cornelia DI Gaetano, Giovanna Tagliabue, Sabina Sieri, Vittorio Krogh

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Breast cancer (BC) is the leading cause of cancer death in women. Adipokines, and other inflammation molecules linked to adiposity, are suspected to be involved in breast carcinogenesis, however prospective findings are inconclusive. In a prospective nested case-control study within the EPIC-Varese cohort, we used conditional logistic regression to estimate rate ratios (RRs) for BC, with 95% confidence intervals (CI), in relation to plasma levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6, leptin, and adiponectin, controlling for BC risk factors. After a median 14.9 years, 351 BC cases were identified and matched to 351 controls. No marker was significantly associated with BC risk overall. Significant interactions between menopausal status and CRP, leptin, and adiponectin were found. Among postmenopausal women, high CRP was significantly associated with increased BC risk, and high adiponectin with significantly reduced risk. Among premenopausal women, high TNF-α was associated with significantly increased risk, and high leptin with reduced risk; interleukin-6 was associated with increased risk only in a continuous model. These findings constitute further evidence that inflammation plays a role in breast cancer. Interventions to lower CRP, TNF-α, and interleukin-6 and increase adiponectin levels may contribute to preventing BC.

Original languageEnglish
Article number12708
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Case-Control Studies
Biomarkers
Breast Neoplasms
Inflammation
Adiponectin
C-Reactive Protein
Leptin
Interleukin-6
Tumor Necrosis Factor-alpha
Adipokines
Adiposity
Cause of Death
Carcinogenesis
Breast
Logistic Models
Confidence Intervals
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Biomarkers of inflammation and breast cancer risk : A case-control study nested in the EPIC-Varese cohort. / Agnoli, Claudia; Grioni, Sara; Pala, Valeria; Allione, Alessandra; Matullo, Giuseppe; Gaetano, Cornelia DI; Tagliabue, Giovanna; Sieri, Sabina; Krogh, Vittorio.

In: Scientific Reports, Vol. 7, No. 1, 12708, 01.12.2017.

Research output: Contribution to journalArticle

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