Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners

Enrico Casimirri, Mariarita Stendardo, Melissa Bonci, Roberta Andreoli, Barbara Bottazzi, Roberto Leone, Michela Schito, Alice Vaccari, Alberto Papi, Marco Contoli, Massimo Corradi, Piera Boschetto

Research output: Contribution to journalArticlepeer-review


Objective: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners. Methods: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites ((Formula presented.)), nitrates ((Formula presented.)), pH, hydrogen peroxide (H2O2) and ammonium ((Formula presented.)) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma. Results: Levels of MDA-EBC, 4-HNE-EBC and (Formula presented.)-EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, (Formula presented.)-EBC and pH. 4-HNE-EBC correlated with PTX3. Conclusion: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
Publication statusAccepted/In press - Dec 7 2015


  • Biological effect markers
  • cleaners
  • exhaled breath condensate
  • Pentraxin-3
  • soluble interleukin-1 receptor type II

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis


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