Objective: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners. Methods: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites ((Formula presented.)), nitrates ((Formula presented.)), pH, hydrogen peroxide (H2O2) and ammonium ((Formula presented.)) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma. Results: Levels of MDA-EBC, 4-HNE-EBC and (Formula presented.)-EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, (Formula presented.)-EBC and pH. 4-HNE-EBC correlated with PTX3. Conclusion: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.
- Biological effect markers
- exhaled breath condensate
- soluble interleukin-1 receptor type II
ASJC Scopus subject areas
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis