TY - JOUR
T1 - Biomarkers of oxidative-stress and inflammation in exhaled breath condensate from hospital cleaners
AU - Casimirri, Enrico
AU - Stendardo, Mariarita
AU - Bonci, Melissa
AU - Andreoli, Roberta
AU - Bottazzi, Barbara
AU - Leone, Roberto
AU - Schito, Michela
AU - Vaccari, Alice
AU - Papi, Alberto
AU - Contoli, Marco
AU - Corradi, Massimo
AU - Boschetto, Piera
PY - 2015/12/7
Y1 - 2015/12/7
N2 - Objective: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners. Methods: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites ((Formula presented.)), nitrates ((Formula presented.)), pH, hydrogen peroxide (H2O2) and ammonium ((Formula presented.)) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma. Results: Levels of MDA-EBC, 4-HNE-EBC and (Formula presented.)-EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, (Formula presented.)-EBC and pH. 4-HNE-EBC correlated with PTX3. Conclusion: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.
AB - Objective: We studied the impact of chlorinated agents exposure on exhaled breath condensate (EBC) biomarkers in cleaners. Methods: Malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), nitrites ((Formula presented.)), nitrates ((Formula presented.)), pH, hydrogen peroxide (H2O2) and ammonium ((Formula presented.)) were tested in EBC of 40 cleaners and 40 non-exposed controls. Pentraxin-3 (PTX3) and soluble type II receptor of IL-1 (sIL-1RII) were analyzed also in plasma. Results: Levels of MDA-EBC, 4-HNE-EBC and (Formula presented.)-EBC were higher, while pH-EBC values were lower, in cleaners. MDA-EBC was associated with 4-HNE-EBC, (Formula presented.)-EBC and pH. 4-HNE-EBC correlated with PTX3. Conclusion: Professional exposure to chlorinated agents increases EBC biomarkers of oxidative stress and inflammation.
KW - Biological effect markers
KW - cleaners
KW - exhaled breath condensate
KW - Pentraxin-3
KW - soluble interleukin-1 receptor type II
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U2 - 10.3109/1354750X.2015.1118541
DO - 10.3109/1354750X.2015.1118541
M3 - Article
AN - SCOPUS:84949227382
SP - 1
EP - 8
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
ER -