Biomarkers related to respiratory symptoms and lung function in adults with asthma

Lucia Calciano, Laura Portas, Angelo Guido Corsico, Mario Olivieri, Paolo Degan, Marcello Ferrari, Alessandro Fois, Anna Maria Fratta Pasini, Andrea Pasini, Maria Elisabetta Zanolin, Roberto De Marco, Simone Accordini

Research output: Contribution to journalArticle

Abstract

Background: There is a need for easily measurable biomarkers that are able to identify different levels of asthma severity. Aim: To assess the association between peripheral blood cell counts, fractional nitric oxide in exhaled air (FeNO), urinary biomarkers of oxidative stress (8-hydroxy-2′-deoxyguanosine and 8-isoprostane), and asthma severity in adult patients from the general population. Methods: In the Gene Environment Interactions in Respiratory Diseases study, 287 subjects with asthma (aged 20-64) were identified from the general population in Verona (Italy) (2008-2010). Self-reported asthma attacks, asthma-like symptoms and the use of hospital services in the past year were synthesized in a score of respiratory symptoms (SRS). The association of biomarkers with SRS and lung function measures (pre-bronchodilator FEV1% predicted and FEV1/FVC) was assessed using quasi-Poisson and Gaussian regression models, respectively. Results: Eosinophils (ratio of expected scores: RES[95%CI] = 1.19[1.09,1.30]), basophils (RES[95%CI] = 1.24[1.10,1.40]), lymphocytes (RES[95%CI] = 1.27[1.12,1.45]) and FeNO (RES[95%CI] = 1.18[1.02,1.37]) were positively associated with SRS. However, only eosinophils (RES[95%CI] = 1.15[1.02,1.30]) and lymphocytes (RES[95%CI] = 1.25[1.06,1.47]) showed an independent association. Furthermore, eosinophils (change in the expected outcome for 1-SD increase: CEO[95%CI] = -1.18[-2.09, -0.27]%), basophils (CEO[95%CI] = -1.24[-2.16, -0.33]%) and lymphocytes (CEO[95%CI] = -1.07[-1.99, -0.14]%) were individually, but not independently, associated with FEV1/FVC. Finally, neutrophils were negatively associated with FEV1% predicted (CEO[95%CI] = -2.22[-4.00, -0.44]%). Conclusions: We identified a pattern of association between a set of biomarkers and asthma endotypes in adult patients from the general population, which could improve understanding of the heterogeneity and severity of the disease and could be useful in defining targeted therapeutic approaches.

Original languageEnglish
Article number026012
JournalJournal of Breath Research
Volume12
Issue number2
DOIs
Publication statusPublished - Apr 1 2018

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Asthma
Biomarkers
Lung
Eosinophils
8-epi-prostaglandin F2alpha
Basophils
Lymphocytes
Population
Gene-Environment Interaction
Blood Cell Count
Bronchodilator Agents
Italy
Nitric Oxide
Oxidative Stress
Neutrophils
Air
Therapeutics

Keywords

  • asthma severity
  • biomarkers
  • FeNO
  • lung function
  • oxidative stress
  • peripheral blood cells
  • respiratory symptoms

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Biomarkers related to respiratory symptoms and lung function in adults with asthma. / Calciano, Lucia; Portas, Laura; Corsico, Angelo Guido; Olivieri, Mario; Degan, Paolo; Ferrari, Marcello; Fois, Alessandro; Pasini, Anna Maria Fratta; Pasini, Andrea; Zanolin, Maria Elisabetta; De Marco, Roberto; Accordini, Simone.

In: Journal of Breath Research, Vol. 12, No. 2, 026012, 01.04.2018.

Research output: Contribution to journalArticle

Calciano, L, Portas, L, Corsico, AG, Olivieri, M, Degan, P, Ferrari, M, Fois, A, Pasini, AMF, Pasini, A, Zanolin, ME, De Marco, R & Accordini, S 2018, 'Biomarkers related to respiratory symptoms and lung function in adults with asthma', Journal of Breath Research, vol. 12, no. 2, 026012. https://doi.org/10.1088/1752-7163/aa9c86
Calciano, Lucia ; Portas, Laura ; Corsico, Angelo Guido ; Olivieri, Mario ; Degan, Paolo ; Ferrari, Marcello ; Fois, Alessandro ; Pasini, Anna Maria Fratta ; Pasini, Andrea ; Zanolin, Maria Elisabetta ; De Marco, Roberto ; Accordini, Simone. / Biomarkers related to respiratory symptoms and lung function in adults with asthma. In: Journal of Breath Research. 2018 ; Vol. 12, No. 2.
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abstract = "Background: There is a need for easily measurable biomarkers that are able to identify different levels of asthma severity. Aim: To assess the association between peripheral blood cell counts, fractional nitric oxide in exhaled air (FeNO), urinary biomarkers of oxidative stress (8-hydroxy-2′-deoxyguanosine and 8-isoprostane), and asthma severity in adult patients from the general population. Methods: In the Gene Environment Interactions in Respiratory Diseases study, 287 subjects with asthma (aged 20-64) were identified from the general population in Verona (Italy) (2008-2010). Self-reported asthma attacks, asthma-like symptoms and the use of hospital services in the past year were synthesized in a score of respiratory symptoms (SRS). The association of biomarkers with SRS and lung function measures (pre-bronchodilator FEV1{\%} predicted and FEV1/FVC) was assessed using quasi-Poisson and Gaussian regression models, respectively. Results: Eosinophils (ratio of expected scores: RES[95{\%}CI] = 1.19[1.09,1.30]), basophils (RES[95{\%}CI] = 1.24[1.10,1.40]), lymphocytes (RES[95{\%}CI] = 1.27[1.12,1.45]) and FeNO (RES[95{\%}CI] = 1.18[1.02,1.37]) were positively associated with SRS. However, only eosinophils (RES[95{\%}CI] = 1.15[1.02,1.30]) and lymphocytes (RES[95{\%}CI] = 1.25[1.06,1.47]) showed an independent association. Furthermore, eosinophils (change in the expected outcome for 1-SD increase: CEO[95{\%}CI] = -1.18[-2.09, -0.27]{\%}), basophils (CEO[95{\%}CI] = -1.24[-2.16, -0.33]{\%}) and lymphocytes (CEO[95{\%}CI] = -1.07[-1.99, -0.14]{\%}) were individually, but not independently, associated with FEV1/FVC. Finally, neutrophils were negatively associated with FEV1{\%} predicted (CEO[95{\%}CI] = -2.22[-4.00, -0.44]{\%}). Conclusions: We identified a pattern of association between a set of biomarkers and asthma endotypes in adult patients from the general population, which could improve understanding of the heterogeneity and severity of the disease and could be useful in defining targeted therapeutic approaches.",
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T1 - Biomarkers related to respiratory symptoms and lung function in adults with asthma

AU - Calciano, Lucia

AU - Portas, Laura

AU - Corsico, Angelo Guido

AU - Olivieri, Mario

AU - Degan, Paolo

AU - Ferrari, Marcello

AU - Fois, Alessandro

AU - Pasini, Anna Maria Fratta

AU - Pasini, Andrea

AU - Zanolin, Maria Elisabetta

AU - De Marco, Roberto

AU - Accordini, Simone

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: There is a need for easily measurable biomarkers that are able to identify different levels of asthma severity. Aim: To assess the association between peripheral blood cell counts, fractional nitric oxide in exhaled air (FeNO), urinary biomarkers of oxidative stress (8-hydroxy-2′-deoxyguanosine and 8-isoprostane), and asthma severity in adult patients from the general population. Methods: In the Gene Environment Interactions in Respiratory Diseases study, 287 subjects with asthma (aged 20-64) were identified from the general population in Verona (Italy) (2008-2010). Self-reported asthma attacks, asthma-like symptoms and the use of hospital services in the past year were synthesized in a score of respiratory symptoms (SRS). The association of biomarkers with SRS and lung function measures (pre-bronchodilator FEV1% predicted and FEV1/FVC) was assessed using quasi-Poisson and Gaussian regression models, respectively. Results: Eosinophils (ratio of expected scores: RES[95%CI] = 1.19[1.09,1.30]), basophils (RES[95%CI] = 1.24[1.10,1.40]), lymphocytes (RES[95%CI] = 1.27[1.12,1.45]) and FeNO (RES[95%CI] = 1.18[1.02,1.37]) were positively associated with SRS. However, only eosinophils (RES[95%CI] = 1.15[1.02,1.30]) and lymphocytes (RES[95%CI] = 1.25[1.06,1.47]) showed an independent association. Furthermore, eosinophils (change in the expected outcome for 1-SD increase: CEO[95%CI] = -1.18[-2.09, -0.27]%), basophils (CEO[95%CI] = -1.24[-2.16, -0.33]%) and lymphocytes (CEO[95%CI] = -1.07[-1.99, -0.14]%) were individually, but not independently, associated with FEV1/FVC. Finally, neutrophils were negatively associated with FEV1% predicted (CEO[95%CI] = -2.22[-4.00, -0.44]%). Conclusions: We identified a pattern of association between a set of biomarkers and asthma endotypes in adult patients from the general population, which could improve understanding of the heterogeneity and severity of the disease and could be useful in defining targeted therapeutic approaches.

AB - Background: There is a need for easily measurable biomarkers that are able to identify different levels of asthma severity. Aim: To assess the association between peripheral blood cell counts, fractional nitric oxide in exhaled air (FeNO), urinary biomarkers of oxidative stress (8-hydroxy-2′-deoxyguanosine and 8-isoprostane), and asthma severity in adult patients from the general population. Methods: In the Gene Environment Interactions in Respiratory Diseases study, 287 subjects with asthma (aged 20-64) were identified from the general population in Verona (Italy) (2008-2010). Self-reported asthma attacks, asthma-like symptoms and the use of hospital services in the past year were synthesized in a score of respiratory symptoms (SRS). The association of biomarkers with SRS and lung function measures (pre-bronchodilator FEV1% predicted and FEV1/FVC) was assessed using quasi-Poisson and Gaussian regression models, respectively. Results: Eosinophils (ratio of expected scores: RES[95%CI] = 1.19[1.09,1.30]), basophils (RES[95%CI] = 1.24[1.10,1.40]), lymphocytes (RES[95%CI] = 1.27[1.12,1.45]) and FeNO (RES[95%CI] = 1.18[1.02,1.37]) were positively associated with SRS. However, only eosinophils (RES[95%CI] = 1.15[1.02,1.30]) and lymphocytes (RES[95%CI] = 1.25[1.06,1.47]) showed an independent association. Furthermore, eosinophils (change in the expected outcome for 1-SD increase: CEO[95%CI] = -1.18[-2.09, -0.27]%), basophils (CEO[95%CI] = -1.24[-2.16, -0.33]%) and lymphocytes (CEO[95%CI] = -1.07[-1.99, -0.14]%) were individually, but not independently, associated with FEV1/FVC. Finally, neutrophils were negatively associated with FEV1% predicted (CEO[95%CI] = -2.22[-4.00, -0.44]%). Conclusions: We identified a pattern of association between a set of biomarkers and asthma endotypes in adult patients from the general population, which could improve understanding of the heterogeneity and severity of the disease and could be useful in defining targeted therapeutic approaches.

KW - asthma severity

KW - biomarkers

KW - FeNO

KW - lung function

KW - oxidative stress

KW - peripheral blood cells

KW - respiratory symptoms

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