TY - JOUR
T1 - Biomarkes of aging
AU - Vasto, Sonya
AU - Scapagnini, Giovanni
AU - Bulati, Matteo
AU - Candore, Giuseppina
AU - Castiglia, Laura
AU - Colonna-Romano, Giuseppina
AU - Lio, Domenico
AU - Nuzzo, Domenico
AU - Pellicano, Mariavaleria
AU - Rizzo, Claudia
AU - Ferrara, Nicola
AU - Caruso, Calogero
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Aging is a complex process that negatively impacts the development of the different systems and its ability to function. Moreover, the Aging rate in humans is not the same, principally due to genetic heterogeneity and environmental factors. The aging rate is measured as the decline of functional capacity and stress resistance. Therefore, several attempts have been made to analyse the individual age, (so-called biological age) compared to chronological age. The biomarkers of aging are age-related body function or composition, these markers aim to assess the biological age and predict the onset of age-related diseases and/or residual lifetime. Such biomarkers should help in one hand to characterise the biological age and on the other hand to identify individuals at high risk of developing age-associated diseases or disabilities. Unfortunately, most of the markers under discussion are related to age-related diseases rather than to age, so none of these markers discussed in literature is a true biomarker of aging. Hence, we discuss some disease-related biomarkers useful for a better understanding of aging and the development of new strategies to counteract it, essential for improving the quality of life of the elderly population.
AB - Aging is a complex process that negatively impacts the development of the different systems and its ability to function. Moreover, the Aging rate in humans is not the same, principally due to genetic heterogeneity and environmental factors. The aging rate is measured as the decline of functional capacity and stress resistance. Therefore, several attempts have been made to analyse the individual age, (so-called biological age) compared to chronological age. The biomarkers of aging are age-related body function or composition, these markers aim to assess the biological age and predict the onset of age-related diseases and/or residual lifetime. Such biomarkers should help in one hand to characterise the biological age and on the other hand to identify individuals at high risk of developing age-associated diseases or disabilities. Unfortunately, most of the markers under discussion are related to age-related diseases rather than to age, so none of these markers discussed in literature is a true biomarker of aging. Hence, we discuss some disease-related biomarkers useful for a better understanding of aging and the development of new strategies to counteract it, essential for improving the quality of life of the elderly population.
KW - Aging
KW - Biomarkers
KW - Immunosenescence
KW - Inflammation
KW - Review
UR - http://www.scopus.com/inward/record.url?scp=84883439095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883439095&partnerID=8YFLogxK
M3 - Article
C2 - 20036955
AN - SCOPUS:84883439095
VL - 2 S
SP - 392
EP - 402
JO - Frontiers in Bioscience - Scholar
JF - Frontiers in Bioscience - Scholar
SN - 1945-0516
IS - 2
ER -