Biomaterials for osteochondral reconstruction

Elizaveta Kon, Francesco Perdisa, Giuseppe Filardo, Luca Andriolo, Francesco Tentoni, Maurilio Marcacci

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The modern regenerative procedures demonstrated to offer the replacement of the articular surface with a hyaline-like tissue, but the properties of the healthy cartilage tissue are still unmatched by any available substitute. Moreover, the treatment of osteochondral lesions is even more biologically challenging since two different tissues are involved (bone and articular cartilage) with a distinctly different intrinsic healing capacity. For the repair of the entire osteochondral unit, several authors have highlighted the need for biphasic scaffolds, to reproduce the different biological and functional requirements for guiding the growth of the two tissues, and different specific scaffolds have been developed for the treatment of large chondral or osteochondral articular defects. At the time being, among these only two scaffolds used for osteochondral regeneration are commercialized for clinical application. One is a bilayer porous PLGA-calcium-sulphate biopolymer. The second osteochondral scaffold is a nanostructured biomimetic HA-collagen scaffold with a porous 3-D tri-layer composite structure, mimicking the whole osteochondral anatomy. Other osteochondral scaffolds are still under preclinical investigation. In this chapter we focus on reviewing the available evidence on the clinical outcome of these osteochondral scaffolds, as well as on reporting the new biomaterials developed and tested in preclinical studies that show to be promising for osteochondral regeneration.

Original languageEnglish
Title of host publicationDeveloping Insights in Cartilage Repair
PublisherSpringer-Verlag London Ltd
Pages99-108
Number of pages10
Volume9781447153856
ISBN (Print)9781447153856, 1447153847, 9781447153849
DOIs
Publication statusPublished - Jun 1 2014

    Fingerprint

Keywords

  • Biomaterial
  • Osteochondral reconstruction
  • Scaffold

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kon, E., Perdisa, F., Filardo, G., Andriolo, L., Tentoni, F., & Marcacci, M. (2014). Biomaterials for osteochondral reconstruction. In Developing Insights in Cartilage Repair (Vol. 9781447153856, pp. 99-108). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-5385-6_6