Biomechanical characterization of subclinical keratoconus without topographic or tomographic abnormalities

Riccardo Vinciguerra, Renato Ambrósio, Cynthia J. Roberts, Claudio Azzolini, Paolo Vinciguerra

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

PURPOSE: To present a case series of patients with subclinical keratoconus with normal topometric (anterior curvature) and tomographic findings in one eye who showed abnormalities detected by Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) in vivo biomechanical assessment. METHODS: All patients had a complete ophthalmic examination, including the Corvis ST biomechanical measurements, optical tomography, and pachymetry with Pentacam (Oculus Optikgeräte GmbH), and Placidobased topography with either the Nidek (OPD III Nidek, Gamagori, Japan) or CSO platform (Costruzione Strumenti Oftalmici, Florence, Italy). Inclusion criteria were a clinical diagnosis of ectasia in one eye and normal topometric and tomographic findings in the fellow eye (subclinical keratoconus), including a Belin/Ambrósio Enhanced Ectasia total deviation index from the Pentacam with less than 1.6 standard deviations from normative values and a Corvis Biomechanical Index score of greater than 0.5 in both eyes. RESULTS: Tomographic and topographic analysis was normal in one eye and abnormal in the fellow eye in 12 patients. The biomechanical results with the Corvis Biomechanical Index were shown to be abnormal in both eyes of all patients and aided the diagnosis. CONCLUSIONS: Biomechanical analysis showed abnormalities, whereas tomography and topography were normal. Basing on these findings, the authors suggest the use of biomechanics as an additional diagnostic tool.

Original languageEnglish
Pages (from-to)399-407
Number of pages9
JournalJournal of Refractive Surgery
Volume33
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

Fingerprint

Keratoconus
Pathologic Dilatations
Optical Tomography
Biomechanical Phenomena
Italy
Germany
Japan
Tomography

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology

Cite this

Biomechanical characterization of subclinical keratoconus without topographic or tomographic abnormalities. / Vinciguerra, Riccardo; Ambrósio, Renato; Roberts, Cynthia J.; Azzolini, Claudio; Vinciguerra, Paolo.

In: Journal of Refractive Surgery, Vol. 33, No. 6, 01.06.2017, p. 399-407.

Research output: Contribution to journalArticle

Vinciguerra, Riccardo ; Ambrósio, Renato ; Roberts, Cynthia J. ; Azzolini, Claudio ; Vinciguerra, Paolo. / Biomechanical characterization of subclinical keratoconus without topographic or tomographic abnormalities. In: Journal of Refractive Surgery. 2017 ; Vol. 33, No. 6. pp. 399-407.
@article{48faf646d72c464bac8d9540b5b5d797,
title = "Biomechanical characterization of subclinical keratoconus without topographic or tomographic abnormalities",
abstract = "PURPOSE: To present a case series of patients with subclinical keratoconus with normal topometric (anterior curvature) and tomographic findings in one eye who showed abnormalities detected by Corvis ST (Oculus Optikger{\"a}te GmbH, Wetzlar, Germany) in vivo biomechanical assessment. METHODS: All patients had a complete ophthalmic examination, including the Corvis ST biomechanical measurements, optical tomography, and pachymetry with Pentacam (Oculus Optikger{\"a}te GmbH), and Placidobased topography with either the Nidek (OPD III Nidek, Gamagori, Japan) or CSO platform (Costruzione Strumenti Oftalmici, Florence, Italy). Inclusion criteria were a clinical diagnosis of ectasia in one eye and normal topometric and tomographic findings in the fellow eye (subclinical keratoconus), including a Belin/Ambr{\'o}sio Enhanced Ectasia total deviation index from the Pentacam with less than 1.6 standard deviations from normative values and a Corvis Biomechanical Index score of greater than 0.5 in both eyes. RESULTS: Tomographic and topographic analysis was normal in one eye and abnormal in the fellow eye in 12 patients. The biomechanical results with the Corvis Biomechanical Index were shown to be abnormal in both eyes of all patients and aided the diagnosis. CONCLUSIONS: Biomechanical analysis showed abnormalities, whereas tomography and topography were normal. Basing on these findings, the authors suggest the use of biomechanics as an additional diagnostic tool.",
author = "Riccardo Vinciguerra and Renato Ambr{\'o}sio and Roberts, {Cynthia J.} and Claudio Azzolini and Paolo Vinciguerra",
year = "2017",
month = "6",
day = "1",
doi = "10.3928/1081597X-20170213-01",
language = "English",
volume = "33",
pages = "399--407",
journal = "Journal of Refractive Surgery",
issn = "1081-597X",
publisher = "Slack Incorporated",
number = "6",

}

TY - JOUR

T1 - Biomechanical characterization of subclinical keratoconus without topographic or tomographic abnormalities

AU - Vinciguerra, Riccardo

AU - Ambrósio, Renato

AU - Roberts, Cynthia J.

AU - Azzolini, Claudio

AU - Vinciguerra, Paolo

PY - 2017/6/1

Y1 - 2017/6/1

N2 - PURPOSE: To present a case series of patients with subclinical keratoconus with normal topometric (anterior curvature) and tomographic findings in one eye who showed abnormalities detected by Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) in vivo biomechanical assessment. METHODS: All patients had a complete ophthalmic examination, including the Corvis ST biomechanical measurements, optical tomography, and pachymetry with Pentacam (Oculus Optikgeräte GmbH), and Placidobased topography with either the Nidek (OPD III Nidek, Gamagori, Japan) or CSO platform (Costruzione Strumenti Oftalmici, Florence, Italy). Inclusion criteria were a clinical diagnosis of ectasia in one eye and normal topometric and tomographic findings in the fellow eye (subclinical keratoconus), including a Belin/Ambrósio Enhanced Ectasia total deviation index from the Pentacam with less than 1.6 standard deviations from normative values and a Corvis Biomechanical Index score of greater than 0.5 in both eyes. RESULTS: Tomographic and topographic analysis was normal in one eye and abnormal in the fellow eye in 12 patients. The biomechanical results with the Corvis Biomechanical Index were shown to be abnormal in both eyes of all patients and aided the diagnosis. CONCLUSIONS: Biomechanical analysis showed abnormalities, whereas tomography and topography were normal. Basing on these findings, the authors suggest the use of biomechanics as an additional diagnostic tool.

AB - PURPOSE: To present a case series of patients with subclinical keratoconus with normal topometric (anterior curvature) and tomographic findings in one eye who showed abnormalities detected by Corvis ST (Oculus Optikgeräte GmbH, Wetzlar, Germany) in vivo biomechanical assessment. METHODS: All patients had a complete ophthalmic examination, including the Corvis ST biomechanical measurements, optical tomography, and pachymetry with Pentacam (Oculus Optikgeräte GmbH), and Placidobased topography with either the Nidek (OPD III Nidek, Gamagori, Japan) or CSO platform (Costruzione Strumenti Oftalmici, Florence, Italy). Inclusion criteria were a clinical diagnosis of ectasia in one eye and normal topometric and tomographic findings in the fellow eye (subclinical keratoconus), including a Belin/Ambrósio Enhanced Ectasia total deviation index from the Pentacam with less than 1.6 standard deviations from normative values and a Corvis Biomechanical Index score of greater than 0.5 in both eyes. RESULTS: Tomographic and topographic analysis was normal in one eye and abnormal in the fellow eye in 12 patients. The biomechanical results with the Corvis Biomechanical Index were shown to be abnormal in both eyes of all patients and aided the diagnosis. CONCLUSIONS: Biomechanical analysis showed abnormalities, whereas tomography and topography were normal. Basing on these findings, the authors suggest the use of biomechanics as an additional diagnostic tool.

UR - http://www.scopus.com/inward/record.url?scp=85020474185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020474185&partnerID=8YFLogxK

U2 - 10.3928/1081597X-20170213-01

DO - 10.3928/1081597X-20170213-01

M3 - Article

AN - SCOPUS:85020474185

VL - 33

SP - 399

EP - 407

JO - Journal of Refractive Surgery

JF - Journal of Refractive Surgery

SN - 1081-597X

IS - 6

ER -