Biomechanical considerations in the pathogenesis of osteoarthritis of the knee

Andras Heijink, Andreas H. Gomoll, Henning Madry, Matej Drobnič, Giuseppe Filardo, João Espregueira-Mendes, C. Niek van Dijk

Research output: Contribution to journalArticlepeer-review


Osteoarthritis is the most common joint disease and a major cause of disability. The knee is the large joint most affected. While chronological age is the single most important risk factor of osteoarthritis, the pathogenesis of knee osteoarthritis in the young patient is predominantly related to an unfavorable biomechanical environment at the joint. This results in mechanical demand that exceeds the ability of a joint to repair and maintain itself, predisposing the articular cartilage to premature degeneration. This review examines the available basic science, preclinical and clinical evidence regarding several such unfavorable biomechanical conditions about the knee: malalignment, loss of meniscal tissue, cartilage defects and joint instability or laxity. Level of evidence IV.

Original languageEnglish
Pages (from-to)423-435
Number of pages13
JournalKnee Surgery, Sports Traumatology, Arthroscopy
Issue number3
Publication statusPublished - Mar 2012


  • Cartilage
  • Etiology
  • Joint instability
  • Malalignment
  • Meniscus
  • Osteochondral defects
  • Pathology

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery


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