Biomimesis and biomorphic transformations: New concepts applied to bone regeneration

Simone Sprio, Andrea Ruffini, Federica Valentini, Teresa D'Alessandro, Monica Sandri, Silvia Panseri, Anna Tampieri

Research output: Contribution to journalArticle

Abstract

In the last decades the activity of material scientists was more and more directed to the development of biomimetic scaffolds, able to drive and address cell activity towards proper differentiation and the repair of diseased human tissues. In case of bone, this requires the synthesis of three-dimensional constructs able to exchange chemical signals promoting osteogenesis and to progressively be resorbed during the formation and remodelling of new bone. Besides, particularly for the regeneration of extensive portions of bone, a morphological and mechanical biomimesis is also required, to allow cell colonization and formation of a proper vascularization tree. The healing of load-bearing bones also requires scaffolds with a hierarchically organized morphology, to provide improved biomechanical behaviour and allow a proper mechano-transduction of the mechanical stimuli down to the cell level. The present paper is an overview of the current technologies and devices developed in the last decade for the regeneration of bone tissue. In particular, novel biomimetic and biomorphic scaffolds, obtained by the controlled transformation of native ligneous structures, promise to adequately face the problem of obtaining complex hierarchical structures, not achievable otherwise by any currently existing manufacturing techniques.

Original languageEnglish
Pages (from-to)347-355
Number of pages9
JournalJournal of Biotechnology
Volume156
Issue number4
DOIs
Publication statusPublished - Dec 20 2010

Fingerprint

Bone Regeneration
Bone
Bone and Bones
Biomimetics
Regeneration
Scaffolds (biology)
Bearings (structural)
Bone Remodeling
Tissue
Weight-Bearing
Osteogenesis
Scaffolds
Technology
Ion exchange
Repair
Equipment and Supplies

Keywords

  • Biomimesis
  • Biomorphic transformation
  • Bone
  • Hierarchical structures
  • Natural template
  • Regenerative medicine

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Sprio, S., Ruffini, A., Valentini, F., D'Alessandro, T., Sandri, M., Panseri, S., & Tampieri, A. (2010). Biomimesis and biomorphic transformations: New concepts applied to bone regeneration. Journal of Biotechnology, 156(4), 347-355. https://doi.org/10.1016/j.jbiotec.2011.07.034

Biomimesis and biomorphic transformations : New concepts applied to bone regeneration. / Sprio, Simone; Ruffini, Andrea; Valentini, Federica; D'Alessandro, Teresa; Sandri, Monica; Panseri, Silvia; Tampieri, Anna.

In: Journal of Biotechnology, Vol. 156, No. 4, 20.12.2010, p. 347-355.

Research output: Contribution to journalArticle

Sprio, S, Ruffini, A, Valentini, F, D'Alessandro, T, Sandri, M, Panseri, S & Tampieri, A 2010, 'Biomimesis and biomorphic transformations: New concepts applied to bone regeneration', Journal of Biotechnology, vol. 156, no. 4, pp. 347-355. https://doi.org/10.1016/j.jbiotec.2011.07.034
Sprio S, Ruffini A, Valentini F, D'Alessandro T, Sandri M, Panseri S et al. Biomimesis and biomorphic transformations: New concepts applied to bone regeneration. Journal of Biotechnology. 2010 Dec 20;156(4):347-355. https://doi.org/10.1016/j.jbiotec.2011.07.034
Sprio, Simone ; Ruffini, Andrea ; Valentini, Federica ; D'Alessandro, Teresa ; Sandri, Monica ; Panseri, Silvia ; Tampieri, Anna. / Biomimesis and biomorphic transformations : New concepts applied to bone regeneration. In: Journal of Biotechnology. 2010 ; Vol. 156, No. 4. pp. 347-355.
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