TY - JOUR
T1 - Biomimetic Intraneural Sensory Feedback Enhances Sensation Naturalness, Tactile Sensitivity, and Manual Dexterity in a Bidirectional Prosthesis
AU - Valle, Giacomo
AU - Mazzoni, Alberto
AU - Iberite, Francesco
AU - D'Anna, Edoardo
AU - Strauss, Ivo
AU - Granata, Giuseppe
AU - Controzzi, Marco
AU - Clemente, Francesco
AU - Rognini, Giulio
AU - Cipriani, Christian
AU - Stieglitz, Thomas
AU - Petrini, Francesco Maria
AU - Rossini, Paolo Maria
AU - Micera, Silvestro
PY - 2018/10/10
Y1 - 2018/10/10
N2 - Peripheral intraneural stimulation can provide tactile information to amputees. However, efforts are still necessary to identify encoding strategy eliciting percepts that are felt as both natural and effective for prosthesis control. Here we compared the naturalness and efficacy of different encoding strategies to deliver neural stimulation to trans-radial amputees implanted with intraneural electrodes. Biomimetic frequency modulation was perceived as more natural, while amplitude modulation enabled better performance in tasks requiring fine identification of the applied force. Notably, the optimal combination of naturalness and sensitivity of the tactile feedback can be achieved with “hybrid” encoding strategies based on simultaneous biomimetic frequency and amplitude neuromodulation. These strategies improved the gross manual dexterity of the subjects during functional task while maintaining high levels of manual accuracy. They also improved prosthesis embodiment, reducing abnormal phantom limb perceptions (“telescoping effect”). Hybrid strategies are able to provide highly sensitive and natural percepts and should be preferred. Video Abstract: Sensory encoding strategies are used to convey sensory information to upper limb amputees. Valle et al. present strategies based on biomimetic approaches that improve sensation naturalness, tactile sensitivity, manual dexterity, and prosthesis embodiment.
AB - Peripheral intraneural stimulation can provide tactile information to amputees. However, efforts are still necessary to identify encoding strategy eliciting percepts that are felt as both natural and effective for prosthesis control. Here we compared the naturalness and efficacy of different encoding strategies to deliver neural stimulation to trans-radial amputees implanted with intraneural electrodes. Biomimetic frequency modulation was perceived as more natural, while amplitude modulation enabled better performance in tasks requiring fine identification of the applied force. Notably, the optimal combination of naturalness and sensitivity of the tactile feedback can be achieved with “hybrid” encoding strategies based on simultaneous biomimetic frequency and amplitude neuromodulation. These strategies improved the gross manual dexterity of the subjects during functional task while maintaining high levels of manual accuracy. They also improved prosthesis embodiment, reducing abnormal phantom limb perceptions (“telescoping effect”). Hybrid strategies are able to provide highly sensitive and natural percepts and should be preferred. Video Abstract: Sensory encoding strategies are used to convey sensory information to upper limb amputees. Valle et al. present strategies based on biomimetic approaches that improve sensation naturalness, tactile sensitivity, manual dexterity, and prosthesis embodiment.
KW - amputee
KW - biomimetic
KW - encoding strategies
KW - hand prosthesis
KW - implantable electrodes
KW - mechanoreceptors models
KW - neural interface
KW - peripheral nerve stimulation
KW - sensation naturalness
KW - sensory feedback
KW - tactile sensory feedback
KW - upper limb amputation
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UR - http://www.scopus.com/inward/citedby.url?scp=85054748317&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2018.08.033
DO - 10.1016/j.neuron.2018.08.033
M3 - Article
C2 - 30244887
AN - SCOPUS:85054748317
VL - 100
SP - 37-45.e7
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 1
ER -