Biomimetic magnetic silk scaffolds

Sangram K. Samal; Mamoni Dash; Tatiana Shelyakova; Heidi A. Declercq; Marc Uhlarz; Manuel Bañobre-López; Peter Dubruel; Maria Cornelissen; Thomas Herrmannsdörfer; Jose Rivas; Giuseppina Padeletti; Stefaan De Smedt; Kevin Braeckmans; David L. Kaplan; V. Alek Dediu

doi:10.1021/acsami.5b00529

Biomimetic magnetic silk scaffolds

Sangram K. Samal, Mamoni Dash, Tatiana Shelyakova, Heidi A. Declercq, Marc Uhlarz, Manuel Bañobre-López, Peter Dubruel, Maria Cornelissen, Thomas Herrmannsdörfer, Jose Rivas, Giuseppina Padeletti, Stefaan De Smedt, Kevin Braeckmans, David L. Kaplan, V. Alek Dediu

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 °C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.

Original language	English
Pages (from-to)	6282-6292
Number of pages	11
Journal	ACS Applied Materials and Interfaces
Volume	7
Issue number	11
DOIs	https://doi.org/10.1021/acsami.5b00529
Publication status	Published - Mar 25 2015

Keywords

biomaterials
hyperthermia
magnetic field
magnetic gradient
magnetic nanoparticles
magnetic scaffold
silk protein
tissue engineering

ASJC Scopus subject areas

Materials Science(all)
Medicine(all)

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10.1021/acsami.5b00529

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title = "Biomimetic magnetic silk scaffolds",

abstract = "Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 °C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.",

keywords = "biomaterials, hyperthermia, magnetic field, magnetic gradient, magnetic nanoparticles, magnetic scaffold, silk protein, tissue engineering",

author = "Samal, {Sangram K.} and Mamoni Dash and Tatiana Shelyakova and Declercq, {Heidi A.} and Marc Uhlarz and Manuel Ba{\~n}obre-L{\'o}pez and Peter Dubruel and Maria Cornelissen and Thomas Herrmannsd{\"o}rfer and Jose Rivas and Giuseppina Padeletti and {De Smedt}, Stefaan and Kevin Braeckmans and Kaplan, {David L.} and Dediu, {V. Alek}",

year = "2015",

month = mar,

day = "25",

doi = "10.1021/acsami.5b00529",

language = "English",

volume = "7",

pages = "6282--6292",

journal = "ACS applied materials & interfaces",

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T1 - Biomimetic magnetic silk scaffolds

AU - Samal, Sangram K.

AU - Dash, Mamoni

AU - Shelyakova, Tatiana

AU - Declercq, Heidi A.

AU - Uhlarz, Marc

AU - Bañobre-López, Manuel

AU - Dubruel, Peter

AU - Cornelissen, Maria

AU - Herrmannsdörfer, Thomas

AU - Rivas, Jose

AU - Padeletti, Giuseppina

AU - De Smedt, Stefaan

AU - Braeckmans, Kevin

AU - Kaplan, David L.

AU - Dediu, V. Alek

PY - 2015/3/25

Y1 - 2015/3/25

N2 - Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 °C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.

AB - Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 °C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.

KW - biomaterials

KW - hyperthermia

KW - magnetic field

KW - magnetic gradient

KW - magnetic nanoparticles

KW - magnetic scaffold

KW - silk protein

KW - tissue engineering

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U2 - 10.1021/acsami.5b00529

DO - 10.1021/acsami.5b00529

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JO - ACS applied materials & interfaces

JF - ACS applied materials & interfaces

SN - 1944-8244

IS - 11

ER -

Biomimetic magnetic silk scaffolds

Abstract

Keywords

ASJC Scopus subject areas

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