Biomimetic magnetic silk scaffolds

Sangram K. Samal, Mamoni Dash, Tatiana Shelyakova, Heidi A. Declercq, Marc Uhlarz, Manuel Bañobre-López, Peter Dubruel, Maria Cornelissen, Thomas Herrmannsdörfer, Jose Rivas, Giuseppina Padeletti, Stefaan De Smedt, Kevin Braeckmans, David L. Kaplan, V. Alek Dediu

Research output: Contribution to journalArticle

Abstract

Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 °C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.

Original languageEnglish
Pages (from-to)6282-6292
Number of pages11
JournalACS Applied Materials and Interfaces
Volume7
Issue number11
DOIs
Publication statusPublished - Mar 25 2015

Keywords

  • biomaterials
  • hyperthermia
  • magnetic field
  • magnetic gradient
  • magnetic nanoparticles
  • magnetic scaffold
  • silk protein
  • tissue engineering

ASJC Scopus subject areas

  • Materials Science(all)
  • Medicine(all)

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  • Cite this

    Samal, S. K., Dash, M., Shelyakova, T., Declercq, H. A., Uhlarz, M., Bañobre-López, M., Dubruel, P., Cornelissen, M., Herrmannsdörfer, T., Rivas, J., Padeletti, G., De Smedt, S., Braeckmans, K., Kaplan, D. L., & Dediu, V. A. (2015). Biomimetic magnetic silk scaffolds. ACS Applied Materials and Interfaces, 7(11), 6282-6292. https://doi.org/10.1021/acsami.5b00529