Biomimetic magnetic silk scaffolds

Sangram K. Samal; Mamoni Dash; Tatiana Shelyakova; Heidi A. Declercq; Marc Uhlarz; Manuel Bañobre-López; Peter Dubruel; Maria Cornelissen; Thomas Herrmannsdörfer; Jose Rivas; Giuseppina Padeletti; Stefaan De Smedt; Kevin Braeckmans; David L. Kaplan; V. Alek Dediu

doi:10.1021/acsami.5b00529

Biomimetic magnetic silk scaffolds

Sangram K. Samal, Mamoni Dash, Tatiana Shelyakova, Heidi A. Declercq, Marc Uhlarz, Manuel Bañobre-López, Peter Dubruel, Maria Cornelissen, Thomas Herrmannsdörfer, Jose Rivas, Giuseppina Padeletti, Stefaan De Smedt, Kevin Braeckmans, David L. Kaplan, V. Alek Dediu

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 °C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.

Original language	English
Pages (from-to)	6282-6292
Number of pages	11
Journal	ACS Applied Materials and Interfaces
Volume	7
Issue number	11
DOIs	https://doi.org/10.1021/acsami.5b00529
Publication status	Published - Mar 25 2015

Keywords

biomaterials
hyperthermia
magnetic field
magnetic gradient
magnetic nanoparticles
magnetic scaffold
silk protein
tissue engineering

ASJC Scopus subject areas

Materials Science(all)
Medicine(all)

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Biomimetic magnetic silk scaffolds. / Samal, Sangram K.; Dash, Mamoni; Shelyakova, Tatiana; Declercq, Heidi A.; Uhlarz, Marc; Bañobre-López, Manuel; Dubruel, Peter; Cornelissen, Maria; Herrmannsdörfer, Thomas; Rivas, Jose; Padeletti, Giuseppina; De Smedt, Stefaan; Braeckmans, Kevin; Kaplan, David L.; Dediu, V. Alek.

In: ACS Applied Materials and Interfaces, Vol. 7, No. 11, 25.03.2015, p. 6282-6292.

Research output: Contribution to journal › Article › peer-review

Samal, Sangram K. ; Dash, Mamoni ; Shelyakova, Tatiana ; Declercq, Heidi A. ; Uhlarz, Marc ; Bañobre-López, Manuel ; Dubruel, Peter ; Cornelissen, Maria ; Herrmannsdörfer, Thomas ; Rivas, Jose ; Padeletti, Giuseppina ; De Smedt, Stefaan ; Braeckmans, Kevin ; Kaplan, David L. ; Dediu, V. Alek. / Biomimetic magnetic silk scaffolds. In: ACS Applied Materials and Interfaces. 2015 ; Vol. 7, No. 11. pp. 6282-6292.

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abstract = "Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 °C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.",

keywords = "biomaterials, hyperthermia, magnetic field, magnetic gradient, magnetic nanoparticles, magnetic scaffold, silk protein, tissue engineering",

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AU - Cornelissen, Maria

AU - Herrmannsdörfer, Thomas

AU - Rivas, Jose

AU - Padeletti, Giuseppina

AU - De Smedt, Stefaan

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Biomimetic magnetic silk scaffolds

Abstract

Keywords

ASJC Scopus subject areas

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