Abstract
Magnetic silk fibroin protein (SFP) scaffolds integrating magnetic materials and featuring magnetic gradients were prepared for potential utility in magnetic-field assisted tissue engineering. Magnetic nanoparticles (MNPs) were introduced into SFP scaffolds via dip-coating methods, resulting in magnetic SFP scaffolds with different strengths of magnetization. Magnetic SFP scaffolds showed excellent hyperthermia properties achieving temperature increases up to 8 °C in about 100 s. The scaffolds were not toxic to osteogenic cells and improved cell adhesion and proliferation. These findings suggest that tailored magnetized silk-based biomaterials can be engineered with interesting features for biomaterials and tissue-engineering applications.
Original language | English |
---|---|
Pages (from-to) | 6282-6292 |
Number of pages | 11 |
Journal | ACS Applied Materials and Interfaces |
Volume | 7 |
Issue number | 11 |
DOIs | |
Publication status | Published - Mar 25 2015 |
Keywords
- biomaterials
- hyperthermia
- magnetic field
- magnetic gradient
- magnetic nanoparticles
- magnetic scaffold
- silk protein
- tissue engineering
ASJC Scopus subject areas
- Materials Science(all)
- Medicine(all)