Biomimetic proteolipid vesicles for targeting inflamed tissues

Roberto Molinaro, Claudia Corbo, Jonathan O. Martinez, Francesca Taraballi, Michael Evangelopoulos, Silvia Minardi, Iman K. Yazdi, P. Zhao, Enrica De Rosa, M. B. Sherman, Alessandro De Vita, Naama E. Toledano Furman, X. Wang, Alessandro Parodi, Ennio Tasciotti

Research output: Contribution to journalArticle

Abstract

A multitude of micro- and nanoparticles have been developed to improve the delivery of systemically administered pharmaceuticals, which are subject to a number of biological barriers that limit their optimal biodistribution. Bioinspired drug-delivery carriers formulated by bottom-up or top-down strategies have emerged as an alternative approach to evade the mononuclear phagocytic system and facilitate transport across the endothelial vessel wall. Here, we describe a method that leverages the advantages of bottom-up and top-down strategies to incorporate proteins derived from the leukocyte plasma membrane into lipid nanoparticles. The resulting proteolipid vesicles—which we refer to as leukosomes—retained the versatility and physicochemical properties typical of liposomal formulations, preferentially targeted inflamed vasculature, enabled the selective and effective delivery of dexamethasone to inflamed tissues, and reduced phlogosis in a localized model of inflammation.

Original languageEnglish
JournalNature Materials
DOIs
Publication statusAccepted/In press - May 23 2016

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Condensed Matter Physics
  • Materials Science(all)
  • Chemistry(all)

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  • Cite this

    Molinaro, R., Corbo, C., Martinez, J. O., Taraballi, F., Evangelopoulos, M., Minardi, S., Yazdi, I. K., Zhao, P., De Rosa, E., Sherman, M. B., De Vita, A., Toledano Furman, N. E., Wang, X., Parodi, A., & Tasciotti, E. (Accepted/In press). Biomimetic proteolipid vesicles for targeting inflamed tissues. Nature Materials. https://doi.org/10.1038/nmat4644