Biomimetic Tissue Engineering: Tuning the Immune and Inflammatory Response to Implantable Biomaterials

Francesca Taraballi, Manuela Sushnitha, Christopher Tsao, Guillermo Bauza, Chiara Liverani, Aaron Shi, Ennio Tasciotti

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Regenerative medicine technologies rely heavily on the use of well-designed biomaterials for therapeutic applications. The success of implantable biomaterials hinges upon the ability of the chosen biomaterial to negotiate with the biological barriers in vivo. The most significant of these barriers is the immune system, which is composed of a highly coordinated organization of cells that induce an inflammatory response to the implanted biomaterial. Biomimetic platforms have emerged as novel strategies that aim to use the principle of biomimicry as a means of immunomodulation. This principle has manifested itself in the form of biomimetic scaffolds that imitate the composition and structure of biological cells and tissues. Recent work in this area has demonstrated the promising potential these technologies hold in overcoming the barrier of the immune system and, thereby, improve their overall therapeutic efficacy. In this review, a broad overview of the use of these strategies across several diseases and future avenues of research utilizing these platforms is provided.

Original languageEnglish
Article number1800490
JournalAdvanced healthcare materials
Volume7
Issue number17
DOIs
Publication statusPublished - Sep 5 2018

Fingerprint

Biomimetics
Biocompatible Materials
Tissue Engineering
Tissue engineering
Biomaterials
Tuning
Immune system
Immune System
Technology
Forms (concrete)
Regenerative Medicine
Immunomodulation
Hinges
Scaffolds (biology)
Tissue
Therapeutics
Chemical analysis
Research

Keywords

  • foreign body reactions
  • immune tuning materials
  • implantable devices
  • inflammation
  • materials functionalization

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Cite this

Biomimetic Tissue Engineering : Tuning the Immune and Inflammatory Response to Implantable Biomaterials. / Taraballi, Francesca; Sushnitha, Manuela; Tsao, Christopher; Bauza, Guillermo; Liverani, Chiara; Shi, Aaron; Tasciotti, Ennio.

In: Advanced healthcare materials, Vol. 7, No. 17, 1800490, 05.09.2018.

Research output: Contribution to journalArticle

Taraballi, Francesca ; Sushnitha, Manuela ; Tsao, Christopher ; Bauza, Guillermo ; Liverani, Chiara ; Shi, Aaron ; Tasciotti, Ennio. / Biomimetic Tissue Engineering : Tuning the Immune and Inflammatory Response to Implantable Biomaterials. In: Advanced healthcare materials. 2018 ; Vol. 7, No. 17.
@article{4cec601105d54a09b01254fa73f3372b,
title = "Biomimetic Tissue Engineering: Tuning the Immune and Inflammatory Response to Implantable Biomaterials",
abstract = "Regenerative medicine technologies rely heavily on the use of well-designed biomaterials for therapeutic applications. The success of implantable biomaterials hinges upon the ability of the chosen biomaterial to negotiate with the biological barriers in vivo. The most significant of these barriers is the immune system, which is composed of a highly coordinated organization of cells that induce an inflammatory response to the implanted biomaterial. Biomimetic platforms have emerged as novel strategies that aim to use the principle of biomimicry as a means of immunomodulation. This principle has manifested itself in the form of biomimetic scaffolds that imitate the composition and structure of biological cells and tissues. Recent work in this area has demonstrated the promising potential these technologies hold in overcoming the barrier of the immune system and, thereby, improve their overall therapeutic efficacy. In this review, a broad overview of the use of these strategies across several diseases and future avenues of research utilizing these platforms is provided.",
keywords = "foreign body reactions, immune tuning materials, implantable devices, inflammation, materials functionalization",
author = "Francesca Taraballi and Manuela Sushnitha and Christopher Tsao and Guillermo Bauza and Chiara Liverani and Aaron Shi and Ennio Tasciotti",
year = "2018",
month = "9",
day = "5",
doi = "10.1002/adhm.201800490",
language = "English",
volume = "7",
journal = "Advanced healthcare materials",
issn = "2192-2640",
publisher = "John Wiley and Sons Ltd",
number = "17",

}

TY - JOUR

T1 - Biomimetic Tissue Engineering

T2 - Tuning the Immune and Inflammatory Response to Implantable Biomaterials

AU - Taraballi, Francesca

AU - Sushnitha, Manuela

AU - Tsao, Christopher

AU - Bauza, Guillermo

AU - Liverani, Chiara

AU - Shi, Aaron

AU - Tasciotti, Ennio

PY - 2018/9/5

Y1 - 2018/9/5

N2 - Regenerative medicine technologies rely heavily on the use of well-designed biomaterials for therapeutic applications. The success of implantable biomaterials hinges upon the ability of the chosen biomaterial to negotiate with the biological barriers in vivo. The most significant of these barriers is the immune system, which is composed of a highly coordinated organization of cells that induce an inflammatory response to the implanted biomaterial. Biomimetic platforms have emerged as novel strategies that aim to use the principle of biomimicry as a means of immunomodulation. This principle has manifested itself in the form of biomimetic scaffolds that imitate the composition and structure of biological cells and tissues. Recent work in this area has demonstrated the promising potential these technologies hold in overcoming the barrier of the immune system and, thereby, improve their overall therapeutic efficacy. In this review, a broad overview of the use of these strategies across several diseases and future avenues of research utilizing these platforms is provided.

AB - Regenerative medicine technologies rely heavily on the use of well-designed biomaterials for therapeutic applications. The success of implantable biomaterials hinges upon the ability of the chosen biomaterial to negotiate with the biological barriers in vivo. The most significant of these barriers is the immune system, which is composed of a highly coordinated organization of cells that induce an inflammatory response to the implanted biomaterial. Biomimetic platforms have emerged as novel strategies that aim to use the principle of biomimicry as a means of immunomodulation. This principle has manifested itself in the form of biomimetic scaffolds that imitate the composition and structure of biological cells and tissues. Recent work in this area has demonstrated the promising potential these technologies hold in overcoming the barrier of the immune system and, thereby, improve their overall therapeutic efficacy. In this review, a broad overview of the use of these strategies across several diseases and future avenues of research utilizing these platforms is provided.

KW - foreign body reactions

KW - immune tuning materials

KW - implantable devices

KW - inflammation

KW - materials functionalization

UR - http://www.scopus.com/inward/record.url?scp=85050405237&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050405237&partnerID=8YFLogxK

U2 - 10.1002/adhm.201800490

DO - 10.1002/adhm.201800490

M3 - Article

AN - SCOPUS:85050405237

VL - 7

JO - Advanced healthcare materials

JF - Advanced healthcare materials

SN - 2192-2640

IS - 17

M1 - 1800490

ER -