Biomolecular markers in cancer of the tongue

Daris Ferrari, Carla Codecà, Jessica Fiore, Laura Moneghini, Silvano Bosari, Paolo Foa

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis.

Original languageEnglish
Article number412908
JournalJournal of Oncology
DOIs
Publication statusPublished - 2009

Fingerprint

Tongue Neoplasms
Neoplasms
Head and Neck Neoplasms
Tongue
Disease-Free Survival
Proteins
Apoptosis
Neoplasm Metastasis
Incidence

ASJC Scopus subject areas

  • Oncology

Cite this

Ferrari, D., Codecà, C., Fiore, J., Moneghini, L., Bosari, S., & Foa, P. (2009). Biomolecular markers in cancer of the tongue. Journal of Oncology, [412908]. https://doi.org/10.1155/2009/412908

Biomolecular markers in cancer of the tongue. / Ferrari, Daris; Codecà, Carla; Fiore, Jessica; Moneghini, Laura; Bosari, Silvano; Foa, Paolo.

In: Journal of Oncology, 2009.

Research output: Contribution to journalArticle

Ferrari, Daris ; Codecà, Carla ; Fiore, Jessica ; Moneghini, Laura ; Bosari, Silvano ; Foa, Paolo. / Biomolecular markers in cancer of the tongue. In: Journal of Oncology. 2009.
@article{e8f7c0a3f3354b2386a57c227e1b43d3,
title = "Biomolecular markers in cancer of the tongue",
abstract = "The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis.",
author = "Daris Ferrari and Carla Codec{\`a} and Jessica Fiore and Laura Moneghini and Silvano Bosari and Paolo Foa",
year = "2009",
doi = "10.1155/2009/412908",
language = "English",
journal = "Journal of Oncology",
issn = "1687-8450",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Biomolecular markers in cancer of the tongue

AU - Ferrari, Daris

AU - Codecà, Carla

AU - Fiore, Jessica

AU - Moneghini, Laura

AU - Bosari, Silvano

AU - Foa, Paolo

PY - 2009

Y1 - 2009

N2 - The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis.

AB - The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment. Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory. This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis. Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response. More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis.

UR - http://www.scopus.com/inward/record.url?scp=69249215238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69249215238&partnerID=8YFLogxK

U2 - 10.1155/2009/412908

DO - 10.1155/2009/412908

M3 - Article

JO - Journal of Oncology

JF - Journal of Oncology

SN - 1687-8450

M1 - 412908

ER -