TY - JOUR
T1 - Biomonitoring data for assessing aflatoxins and ochratoxin a exposure by italian feedstuffs workers
AU - Santis, Barbara De
AU - Debegnach, Francesca
AU - Sonego, Elisa
AU - Mazzilli, Gianmarco
AU - Buiarelli, Francesca
AU - Ferri, Fulvio
AU - Rossi, Paolo Giorgi
AU - Collini, Giorgia
AU - Brera, Carlo
PY - 2019/6/18
Y1 - 2019/6/18
N2 - Mycotoxins exposure by inhalation and/Or dermal contact is possible in different branches of industry especially where heavily dusty settings are present and the handling of dusty commodities is performed. This study aims to explore the validity of the biomonitoring as a tool to investigate the intake of mycotoxins in a population of workers operating in an Italian feed plant. Serum samples were collected for the determination of aflatoxins B1 (AFB1), AFB1-Lysine adduct and ochratoxin A (OTA). A method based on liquid-Liquid extraction coupled with high resolution mass spectrometry determination was developed and fully validated. For AFB1, a high number of non-Detected samples (90%) was found and no statistical difference was observed comparing workers and control group. None of the analyzed samples showed the presence of AFB1-Lysine adduct. For OTA, the 100% of the analyzed samples was positive with a 33% of the samples showing a concentration higher than the limit of quantification (LOQ), but no statistical difference was highlighted between the average levels of exposed and control groups. In conclusion, the presence of AFB1 and OTA in serum cannot be attributable to occupational exposure.
AB - Mycotoxins exposure by inhalation and/Or dermal contact is possible in different branches of industry especially where heavily dusty settings are present and the handling of dusty commodities is performed. This study aims to explore the validity of the biomonitoring as a tool to investigate the intake of mycotoxins in a population of workers operating in an Italian feed plant. Serum samples were collected for the determination of aflatoxins B1 (AFB1), AFB1-Lysine adduct and ochratoxin A (OTA). A method based on liquid-Liquid extraction coupled with high resolution mass spectrometry determination was developed and fully validated. For AFB1, a high number of non-Detected samples (90%) was found and no statistical difference was observed comparing workers and control group. None of the analyzed samples showed the presence of AFB1-Lysine adduct. For OTA, the 100% of the analyzed samples was positive with a 33% of the samples showing a concentration higher than the limit of quantification (LOQ), but no statistical difference was highlighted between the average levels of exposed and control groups. In conclusion, the presence of AFB1 and OTA in serum cannot be attributable to occupational exposure.
KW - Aflatoxin B1
KW - Biomonitoring
KW - Mycotoxins
KW - Occupational exposure
KW - Ochratoxin A
UR - http://www.scopus.com/inward/record.url?scp=85068496042&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068496042&partnerID=8YFLogxK
U2 - 10.3390/toxins11060351
DO - 10.3390/toxins11060351
M3 - Article
C2 - 31216680
AN - SCOPUS:85068496042
VL - 11
JO - Toxins
JF - Toxins
SN - 2072-6651
IS - 6
M1 - 351
ER -