TY - JOUR
T1 - Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents
T2 - Data from LIFE PERSUADED project
AU - LIFE PERSUADED Project Group
AU - Tait, Sabrina
AU - Carli, Fabrizia
AU - Busani, Luca
AU - Buzzigoli, Emma
AU - Della Latta, Veronica
AU - Deodati, Annalisa
AU - Fabbrizi, Enrica
AU - Gaggini, Melania
AU - Maranghi, Francesca
AU - Tassinari, Roberta
AU - Toffol, Giacomo
AU - Cianfarani, Stefano
AU - Gastaldelli, Amalia
AU - La Rocca, Cinzia
N1 - Funding Information:
This work was supported by the European Commission Directorate-General for Environment, LIFE Programme, Environment Policy and Governance (grant number LIFE13 ENV/IT/000482 ).
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/6
Y1 - 2020/6
N2 - The Bis(2-ethylhexyl)phthalate (DEHP), a widespread plasticizer, is considered an endocrine disrupting chemical with main toxicological effects on reproductive and metabolic systems. Human biomonitoring (HBM) studies are promoted to evaluate the background exposure levels. In the frame of LIFE PERSUADED project, the HBM study measured DEHP main metabolites (mono-(2-ethylhexyl) phthalate, MEHP; 2-ethyl-5-hydroxy-hexylphthalate, MEHHP; 2-ethyl-5-oxo-hexylphthalate, MEOHP) in Italian children and adolescent (4–14 years old) according to geographical macro-areas and areas, age and sex. Children from the South and the Centre of Italy showed higher median levels of DEHP, as a sum of its metabolites (48.14 and 47.80 μg/L), than those from the North (39.47 μg/L; p = 0.0090 and 0.0004, respectively). Considering the total population, boys are more exposed than girls (only as urinary volume), and children aged 4–6 years have higher median levels than those 7–10 and 11–14 years old. The derived reference values (RV95) for DEHP in children is 168 μg/L. The relative metabolic rates of DEHP, the background levels and, thus, the RV95, vary with the geographical area, age and sex, indicating that all these parameters should be considered in the risk assessment.
AB - The Bis(2-ethylhexyl)phthalate (DEHP), a widespread plasticizer, is considered an endocrine disrupting chemical with main toxicological effects on reproductive and metabolic systems. Human biomonitoring (HBM) studies are promoted to evaluate the background exposure levels. In the frame of LIFE PERSUADED project, the HBM study measured DEHP main metabolites (mono-(2-ethylhexyl) phthalate, MEHP; 2-ethyl-5-hydroxy-hexylphthalate, MEHHP; 2-ethyl-5-oxo-hexylphthalate, MEOHP) in Italian children and adolescent (4–14 years old) according to geographical macro-areas and areas, age and sex. Children from the South and the Centre of Italy showed higher median levels of DEHP, as a sum of its metabolites (48.14 and 47.80 μg/L), than those from the North (39.47 μg/L; p = 0.0090 and 0.0004, respectively). Considering the total population, boys are more exposed than girls (only as urinary volume), and children aged 4–6 years have higher median levels than those 7–10 and 11–14 years old. The derived reference values (RV95) for DEHP in children is 168 μg/L. The relative metabolic rates of DEHP, the background levels and, thus, the RV95, vary with the geographical area, age and sex, indicating that all these parameters should be considered in the risk assessment.
KW - Children exposure
KW - Endocrine disruptors
KW - Reference values
KW - Urinary DEHP metabolites
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U2 - 10.1016/j.envres.2020.109428
DO - 10.1016/j.envres.2020.109428
M3 - Article
C2 - 32251910
AN - SCOPUS:85082707342
VL - 185
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
M1 - 109428
ER -