Indicatori di esposizione a idrocarburi aromatici policiclici: Il paradosso pirene-idrossipirene

F. M. Rubino; C. Verduci; M. Buratti; S. Fustinoni; L. Neri; G. Brambilla; A. Colombi

Indicatori di esposizione a idrocarburi aromatici policiclici: Il paradosso pirene-idrossipirene

Translated title of the contribution: Biomonitoring of exposure to pah: The pyrene vs. 1-hydroxypyrene paradox

F. M. Rubino, C. Verduci, M. Buratti, S. Fustinoni, L. Neri, G. Brambilla, A. Colombi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Comparison between the inhaled dose of pyrene by non-smoking subjects exposed to urban airborne contamination and the daily urinary excretion of the main metabolite 1-hydroxypyrene highlights a quantitative inconsistency, since the amount of the metabolite is 10-50 times higher than the inhaled dose of the parent compound. It is suggested that the excessive amount of hydroxypyrene may derive from the slow release of pyrene strongly absorbed or chemically embedded in the carbon soot deposited over a lifetime in the lung alveoli of the subject.

Translated title of the contribution	Biomonitoring of exposure to pah: The pyrene vs. 1-hydroxypyrene paradox
Original language	Italian
Pages (from-to)	98-99
Number of pages	2
Journal	Giornale Italiano di Medicina del Lavoro ed Ergonomia
Volume	26
Issue number	4 SUPPL.
Publication status	Published - 2004

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Rehabilitation

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Cite this

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title = "Indicatori di esposizione a idrocarburi aromatici policiclici: Il paradosso pirene-idrossipirene",

abstract = "Comparison between the inhaled dose of pyrene by non-smoking subjects exposed to urban airborne contamination and the daily urinary excretion of the main metabolite 1-hydroxypyrene highlights a quantitative inconsistency, since the amount of the metabolite is 10-50 times higher than the inhaled dose of the parent compound. It is suggested that the excessive amount of hydroxypyrene may derive from the slow release of pyrene strongly absorbed or chemically embedded in the carbon soot deposited over a lifetime in the lung alveoli of the subject.",

keywords = "1-hydroxypyrene in urine, Airborne pyrene, Environmental exposure",

author = "Rubino, {F. M.} and C. Verduci and M. Buratti and S. Fustinoni and L. Neri and G. Brambilla and A. Colombi",

year = "2004",

language = "Italian",

volume = "26",

pages = "98--99",

journal = "Giornale Italiano di Medicina del Lavoro ed Ergonomia",

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T1 - Indicatori di esposizione a idrocarburi aromatici policiclici

T2 - Il paradosso pirene-idrossipirene

AU - Rubino, F. M.

AU - Verduci, C.

AU - Buratti, M.

AU - Fustinoni, S.

AU - Neri, L.

AU - Brambilla, G.

AU - Colombi, A.

PY - 2004

Y1 - 2004

N2 - Comparison between the inhaled dose of pyrene by non-smoking subjects exposed to urban airborne contamination and the daily urinary excretion of the main metabolite 1-hydroxypyrene highlights a quantitative inconsistency, since the amount of the metabolite is 10-50 times higher than the inhaled dose of the parent compound. It is suggested that the excessive amount of hydroxypyrene may derive from the slow release of pyrene strongly absorbed or chemically embedded in the carbon soot deposited over a lifetime in the lung alveoli of the subject.

AB - Comparison between the inhaled dose of pyrene by non-smoking subjects exposed to urban airborne contamination and the daily urinary excretion of the main metabolite 1-hydroxypyrene highlights a quantitative inconsistency, since the amount of the metabolite is 10-50 times higher than the inhaled dose of the parent compound. It is suggested that the excessive amount of hydroxypyrene may derive from the slow release of pyrene strongly absorbed or chemically embedded in the carbon soot deposited over a lifetime in the lung alveoli of the subject.

KW - 1-hydroxypyrene in urine

KW - Airborne pyrene

KW - Environmental exposure

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JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia

JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia

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