Identificazione di marcatori specifici di esposizione professionale a farmaci antiblastici usati in polichemioterapia: Progetto IMEPA.

Translated title of the contribution: Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project

Claudia Bolognesi, Maria Concetta Nucci, Anna Maria Colacci, Sandro Grilli, Flora Ippoliti, Nicolina Mucci, Vincenzo Romano Spica, Anna Barbieri, Nicoletta Canitano, Daniela Chiozzotto, Livia Di Renzo, Elena Giordano, Wolfango Horn, Paola Roggieri, Alessandro Risi, Paola Silingardi, Monica Vaccari, Francesco Saverio Violante

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs. DESIGN: Molecular epidemiology study. SETTING: S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed to antiblastic drugs. PARTICIPANTS: 50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits. MAIN OUTCOME MEASURES: Urinary markers of exposure, Heat Shock Proteins (HSPs) 27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes: apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors micronuclei; frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2). RESULTS: 19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups. CONCLUSION: This biomonitoring study doesn't evidence any early significant effect associated to the exposure to antiblastic drugs.

Original languageItalian
Pages (from-to)91-95
Number of pages5
JournalEpidemiologia e prevenzione
Volume29
Issue number5-6 Suppl
Publication statusPublished - Sep 2005

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Environmental Monitoring
Antineoplastic Agents
Nurses
Pharmaceutical Preparations
Biomarkers
Lymphocytes
HSP27 Heat-Shock Proteins
Natural Killer Cell Receptors
HSP70 Heat-Shock Proteins
Molecular Epidemiology
Mouth Mucosa
Oncogenes
Italy
Habits
Cell Cycle
Smoking
Apoptosis
Control Groups

Cite this

Bolognesi, C., Nucci, M. C., Colacci, A. M., Grilli, S., Ippoliti, F., Mucci, N., ... Violante, F. S. (2005). Identificazione di marcatori specifici di esposizione professionale a farmaci antiblastici usati in polichemioterapia: Progetto IMEPA. Epidemiologia e prevenzione, 29(5-6 Suppl), 91-95.

Identificazione di marcatori specifici di esposizione professionale a farmaci antiblastici usati in polichemioterapia : Progetto IMEPA. / Bolognesi, Claudia; Nucci, Maria Concetta; Colacci, Anna Maria; Grilli, Sandro; Ippoliti, Flora; Mucci, Nicolina; Spica, Vincenzo Romano; Barbieri, Anna; Canitano, Nicoletta; Chiozzotto, Daniela; Di Renzo, Livia; Giordano, Elena; Horn, Wolfango; Roggieri, Paola; Risi, Alessandro; Silingardi, Paola; Vaccari, Monica; Violante, Francesco Saverio.

In: Epidemiologia e prevenzione, Vol. 29, No. 5-6 Suppl, 09.2005, p. 91-95.

Research output: Contribution to journalArticle

Bolognesi, C, Nucci, MC, Colacci, AM, Grilli, S, Ippoliti, F, Mucci, N, Spica, VR, Barbieri, A, Canitano, N, Chiozzotto, D, Di Renzo, L, Giordano, E, Horn, W, Roggieri, P, Risi, A, Silingardi, P, Vaccari, M & Violante, FS 2005, 'Identificazione di marcatori specifici di esposizione professionale a farmaci antiblastici usati in polichemioterapia: Progetto IMEPA.', Epidemiologia e prevenzione, vol. 29, no. 5-6 Suppl, pp. 91-95.
Bolognesi, Claudia ; Nucci, Maria Concetta ; Colacci, Anna Maria ; Grilli, Sandro ; Ippoliti, Flora ; Mucci, Nicolina ; Spica, Vincenzo Romano ; Barbieri, Anna ; Canitano, Nicoletta ; Chiozzotto, Daniela ; Di Renzo, Livia ; Giordano, Elena ; Horn, Wolfango ; Roggieri, Paola ; Risi, Alessandro ; Silingardi, Paola ; Vaccari, Monica ; Violante, Francesco Saverio. / Identificazione di marcatori specifici di esposizione professionale a farmaci antiblastici usati in polichemioterapia : Progetto IMEPA. In: Epidemiologia e prevenzione. 2005 ; Vol. 29, No. 5-6 Suppl. pp. 91-95.
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title = "Identificazione di marcatori specifici di esposizione professionale a farmaci antiblastici usati in polichemioterapia: Progetto IMEPA.",
abstract = "OBJECTIVE: To develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs. DESIGN: Molecular epidemiology study. SETTING: S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed to antiblastic drugs. PARTICIPANTS: 50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits. MAIN OUTCOME MEASURES: Urinary markers of exposure, Heat Shock Proteins (HSPs) 27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes: apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors micronuclei; frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2). RESULTS: 19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups. CONCLUSION: This biomonitoring study doesn't evidence any early significant effect associated to the exposure to antiblastic drugs.",
author = "Claudia Bolognesi and Nucci, {Maria Concetta} and Colacci, {Anna Maria} and Sandro Grilli and Flora Ippoliti and Nicolina Mucci and Spica, {Vincenzo Romano} and Anna Barbieri and Nicoletta Canitano and Daniela Chiozzotto and {Di Renzo}, Livia and Elena Giordano and Wolfango Horn and Paola Roggieri and Alessandro Risi and Paola Silingardi and Monica Vaccari and Violante, {Francesco Saverio}",
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T1 - Identificazione di marcatori specifici di esposizione professionale a farmaci antiblastici usati in polichemioterapia

T2 - Progetto IMEPA.

AU - Bolognesi, Claudia

AU - Nucci, Maria Concetta

AU - Colacci, Anna Maria

AU - Grilli, Sandro

AU - Ippoliti, Flora

AU - Mucci, Nicolina

AU - Spica, Vincenzo Romano

AU - Barbieri, Anna

AU - Canitano, Nicoletta

AU - Chiozzotto, Daniela

AU - Di Renzo, Livia

AU - Giordano, Elena

AU - Horn, Wolfango

AU - Roggieri, Paola

AU - Risi, Alessandro

AU - Silingardi, Paola

AU - Vaccari, Monica

AU - Violante, Francesco Saverio

PY - 2005/9

Y1 - 2005/9

N2 - OBJECTIVE: To develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs. DESIGN: Molecular epidemiology study. SETTING: S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed to antiblastic drugs. PARTICIPANTS: 50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits. MAIN OUTCOME MEASURES: Urinary markers of exposure, Heat Shock Proteins (HSPs) 27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes: apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors micronuclei; frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2). RESULTS: 19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups. CONCLUSION: This biomonitoring study doesn't evidence any early significant effect associated to the exposure to antiblastic drugs.

AB - OBJECTIVE: To develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs. DESIGN: Molecular epidemiology study. SETTING: S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed to antiblastic drugs. PARTICIPANTS: 50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits. MAIN OUTCOME MEASURES: Urinary markers of exposure, Heat Shock Proteins (HSPs) 27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes: apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors micronuclei; frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2). RESULTS: 19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups. CONCLUSION: This biomonitoring study doesn't evidence any early significant effect associated to the exposure to antiblastic drugs.

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