Identificazione di marcatori specifici di esposizione professionale a farmaci antiblastici usati in polichemioterapia: Progetto IMEPA.

Translated title of the contribution: Biomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project

Claudia Bolognesi, Maria Concetta Nucci, Anna Maria Colacci, Sandro Grilli, Flora Ippoliti, Nicolina Mucci, Vincenzo Romano Spica, Anna Barbieri, Nicoletta Canitano, Daniela Chiozzotto, Livia Di Renzo, Elena Giordano, Wolfango Horn, Paola Roggieri, Alessandro Risi, Paola Silingardi, Monica Vaccari, Francesco Saverio Violante

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To develop a multiple-endpoint monitoring system in order to assess and minimize long term risks in hospital nurses exposed to antiblastic drugs. DESIGN: Molecular epidemiology study. SETTING: S. Orsola-Malpighi Hospital in Bologna, Italy: nurses exposed to antiblastic drugs. PARTICIPANTS: 50 exposed subjects (8 males and 42 females) and 50 unexposed individuals (8 males and 42 females) matched for age and smoking habits. MAIN OUTCOME MEASURES: Urinary markers of exposure, Heat Shock Proteins (HSPs) 27, 70, 90, 110, immunologic biomarkers in peripheral blood lymphocytes: apoptosis, cell-cycle analysis G1-S-G, typization of Natural Killer cells (NK) and receptors micronuclei; frequency in peripheral blood lymphocytes and in exfoliated buccal mucosa cells; activation ofspecific oncogenes (bax, bcl2). RESULTS: 19/50 subjects showed urinary antiblastic drug levels (3 subjects MTX, 11 subjects CP, 5 subjects MTX and CP). No statistically significant differences were observed in all the considered biomarkers between the exposed and control groups. CONCLUSION: This biomonitoring study doesn't evidence any early significant effect associated to the exposure to antiblastic drugs.

Translated title of the contributionBiomonitoring of nurses occupationally exposed to antineoplastic drugs: the IMEPA Project
Original languageItalian
Pages (from-to)91-95
Number of pages5
JournalEpidemiologia e prevenzione
Volume29
Issue number5-6 Suppl
Publication statusPublished - Sep 2005

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