Biopharmacokinetic evaluation of peptichemio (PTC) by reversed-phase high-performance liquid chromatography (HPLC)

preliminary in vitro studies.

P. Montaldo, F. Perrone, P. Cornaglia-Ferraris

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Authors describe a reversed-phase HPLC method for the separation of the six peptides which constitute the antitumoral drug Peptichemio (PTC). They also present some preliminary investigations concerning the in vitro biopharmacokinetics of this drug. Differences in selectivity and kinetics of peptides uptake have been investigated using human peripheral blood lymphocytes (PBL) and a human neuroblastoma derived cell line (SK-N-SH). Results will be discussed along with their clinical and pharmacological research implications.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume66
Issue number1
Publication statusPublished - 1987

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Peptichemio
Reverse-Phase Chromatography
High Pressure Liquid Chromatography
Peptides
Neuroblastoma
Pharmaceutical Preparations
Pharmacology
Lymphocytes
Cell Line
Research
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

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title = "Biopharmacokinetic evaluation of peptichemio (PTC) by reversed-phase high-performance liquid chromatography (HPLC): preliminary in vitro studies.",
abstract = "The Authors describe a reversed-phase HPLC method for the separation of the six peptides which constitute the antitumoral drug Peptichemio (PTC). They also present some preliminary investigations concerning the in vitro biopharmacokinetics of this drug. Differences in selectivity and kinetics of peptides uptake have been investigated using human peripheral blood lymphocytes (PBL) and a human neuroblastoma derived cell line (SK-N-SH). Results will be discussed along with their clinical and pharmacological research implications.",
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