Biopharmacokinetic evaluation of peptichemio (PTC) by reversed-phase high-performance liquid chromatography (HPLC): preliminary in vitro studies.

P. Montaldo, F. Perrone, P. Cornaglia-Ferraris

Research output: Contribution to journalArticlepeer-review

Abstract

The Authors describe a reversed-phase HPLC method for the separation of the six peptides which constitute the antitumoral drug Peptichemio (PTC). They also present some preliminary investigations concerning the in vitro biopharmacokinetics of this drug. Differences in selectivity and kinetics of peptides uptake have been investigated using human peripheral blood lymphocytes (PBL) and a human neuroblastoma derived cell line (SK-N-SH). Results will be discussed along with their clinical and pharmacological research implications.

Original languageEnglish
Pages (from-to)78-85
Number of pages8
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume66
Issue number1
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Biopharmacokinetic evaluation of peptichemio (PTC) by reversed-phase high-performance liquid chromatography (HPLC): preliminary in vitro studies.'. Together they form a unique fingerprint.

Cite this