Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases

Chiara Arrigoni, Mara Gilardi, Simone Bersini, Christian Candrian, Matteo Moretti

Research output: Contribution to journalArticle

Abstract

The skeleton supports and confers structure to the whole body but several pathological and traumatic conditions affect the bone tissue. Most of those pathological conditions are specific and different among different patients, such as bone defects due to traumatic injuries or bone remodeling alterations due to congenital diseases. In this context, the development of personalized therapies would be highly desirable. In recent years the advent of innovative techniques like bioprinting and microfluidic organ-on-chip raised hopes of achieving key tools helping the application of personalized therapies for bone diseases. In this review we will illustrate the latest progresses in the bioprinting of personalized bone grafts and generation of patient-specific bone-on-chip devices, describing current approaches and limitations and possible future improvements for more effective personalized bone grafts and disease models.

Original languageEnglish
Pages (from-to)407-417
Number of pages11
JournalStem Cell Reviews and Reports
Volume13
Issue number3
DOIs
Publication statusPublished - Jun 1 2017

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Keywords

  • Bioprinting
  • Bone tissue models
  • Microfluidics
  • Personalized medicine

ASJC Scopus subject areas

  • Cell Biology
  • Cancer Research

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