Abstract
The skeleton supports and confers structure to the whole body but several pathological and traumatic conditions affect the bone tissue. Most of those pathological conditions are specific and different among different patients, such as bone defects due to traumatic injuries or bone remodeling alterations due to congenital diseases. In this context, the development of personalized therapies would be highly desirable. In recent years the advent of innovative techniques like bioprinting and microfluidic organ-on-chip raised hopes of achieving key tools helping the application of personalized therapies for bone diseases. In this review we will illustrate the latest progresses in the bioprinting of personalized bone grafts and generation of patient-specific bone-on-chip devices, describing current approaches and limitations and possible future improvements for more effective personalized bone grafts and disease models.
| Original language | English |
|---|---|
| Pages (from-to) | 407-417 |
| Number of pages | 11 |
| Journal | Stem Cell Reviews and Reports |
| Volume | 13 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 1 2017 |
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Keywords
- Bioprinting
- Bone tissue models
- Microfluidics
- Personalized medicine
ASJC Scopus subject areas
- Cell Biology
- Cancer Research
Cite this
Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases. / Arrigoni, Chiara; Gilardi, Mara; Bersini, Simone; Candrian, Christian; Moretti, Matteo.
In: Stem Cell Reviews and Reports, Vol. 13, No. 3, 01.06.2017, p. 407-417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bioprinting and Organ-on-Chip Applications Towards Personalized Medicine for Bone Diseases
AU - Arrigoni, Chiara
AU - Gilardi, Mara
AU - Bersini, Simone
AU - Candrian, Christian
AU - Moretti, Matteo
PY - 2017/6/1
Y1 - 2017/6/1
N2 - The skeleton supports and confers structure to the whole body but several pathological and traumatic conditions affect the bone tissue. Most of those pathological conditions are specific and different among different patients, such as bone defects due to traumatic injuries or bone remodeling alterations due to congenital diseases. In this context, the development of personalized therapies would be highly desirable. In recent years the advent of innovative techniques like bioprinting and microfluidic organ-on-chip raised hopes of achieving key tools helping the application of personalized therapies for bone diseases. In this review we will illustrate the latest progresses in the bioprinting of personalized bone grafts and generation of patient-specific bone-on-chip devices, describing current approaches and limitations and possible future improvements for more effective personalized bone grafts and disease models.
AB - The skeleton supports and confers structure to the whole body but several pathological and traumatic conditions affect the bone tissue. Most of those pathological conditions are specific and different among different patients, such as bone defects due to traumatic injuries or bone remodeling alterations due to congenital diseases. In this context, the development of personalized therapies would be highly desirable. In recent years the advent of innovative techniques like bioprinting and microfluidic organ-on-chip raised hopes of achieving key tools helping the application of personalized therapies for bone diseases. In this review we will illustrate the latest progresses in the bioprinting of personalized bone grafts and generation of patient-specific bone-on-chip devices, describing current approaches and limitations and possible future improvements for more effective personalized bone grafts and disease models.
KW - Bioprinting
KW - Bone tissue models
KW - Microfluidics
KW - Personalized medicine
UR - http://www.scopus.com/inward/record.url?scp=85020276853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020276853&partnerID=8YFLogxK
U2 - 10.1007/s12015-017-9741-5
DO - 10.1007/s12015-017-9741-5
M3 - Article
AN - SCOPUS:85020276853
VL - 13
SP - 407
EP - 417
JO - Stem Cell Reviews
JF - Stem Cell Reviews
SN - 1550-8943
IS - 3
ER -