Abstract
The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1-20 |
| Number of pages | 20 |
| Journal | Cancers |
| Volume | 11 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Nov 27 2019 |
Keywords
- TS/A
- murine mammary cancer
- preclinical model
- gene therapy
- metastases
- immunotherapy
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De Giovanni, C., Nicoletti, G., Landuzzi, L., Palladini, A., Lollini, P-L., & Nanni, P. (2019). Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model. Cancers, 11(12), 1-20. https://doi.org/10.3390/cancers11121889