Abstract
The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 1-20 |
| Number of pages | 20 |
| Journal | Cancers |
| Volume | 11 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Nov 27 2019 |
Keywords
- TS/A
- murine mammary cancer
- preclinical model
- gene therapy
- metastases
- immunotherapy
Cite this
Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model. / De Giovanni, Carla; Nicoletti, Giordano; Landuzzi, Lorena; Palladini, Arianna; Lollini, Pier-Luigi; Nanni, Patrizia.
In: Cancers, Vol. 11, No. 12, 27.11.2019, p. 1-20.Research output: Contribution to journal › Review article
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TY - JOUR
T1 - Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model
AU - De Giovanni, Carla
AU - Nicoletti, Giordano
AU - Landuzzi, Lorena
AU - Palladini, Arianna
AU - Lollini, Pier-Luigi
AU - Nanni, Patrizia
PY - 2019/11/27
Y1 - 2019/11/27
N2 - The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.
AB - The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.
KW - TS/A
KW - murine mammary cancer
KW - preclinical model
KW - gene therapy
KW - metastases
KW - immunotherapy
U2 - 10.3390/cancers11121889
DO - 10.3390/cancers11121889
M3 - Review article
C2 - 31783695
VL - 11
SP - 1
EP - 20
JO - Cancers
JF - Cancers
SN - 2072-6694
IS - 12
ER -