Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

Carla De Giovanni, Giordano Nicoletti, Lorena Landuzzi, Arianna Palladini, Pier-Luigi Lollini, Patrizia Nanni

Research output: Contribution to journalReview article

Abstract

The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.

Original languageEnglish
Pages (from-to)1-20
Number of pages20
JournalCancers
Volume11
Issue number12
DOIs
Publication statusPublished - Nov 27 2019

Keywords

  • TS/A
  • murine mammary cancer
  • preclinical model
  • gene therapy
  • metastases
  • immunotherapy

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