Abstract
The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.
Original language | English |
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Pages (from-to) | 1-20 |
Number of pages | 20 |
Journal | Cancers |
Volume | 11 |
Issue number | 12 |
DOIs | |
Publication status | Published - Nov 27 2019 |
Keywords
- TS/A
- murine mammary cancer
- preclinical model
- gene therapy
- metastases
- immunotherapy