Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

Carla De Giovanni; Giordano Nicoletti; Lorena Landuzzi; Arianna Palladini; Pier-Luigi Lollini; Patrizia Nanni

doi:10.3390/cancers11121889

Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

Carla De Giovanni, Giordano Nicoletti, Lorena Landuzzi, Arianna Palladini, Pier-Luigi Lollini, Patrizia Nanni

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Review article › peer-review

Abstract

The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.

Original language	English
Pages (from-to)	1-20
Number of pages	20
Journal	Cancers
Volume	11
Issue number	12
DOIs	https://doi.org/10.3390/cancers11121889
Publication status	Published - Nov 27 2019

Keywords

TS/A
murine mammary cancer
preclinical model
gene therapy
metastases
immunotherapy

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10.3390/cancers11121889

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title = "Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model",

abstract = "The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.",

keywords = "TS/A, murine mammary cancer, preclinical model, gene therapy, metastases, immunotherapy",

author = "{De Giovanni}, Carla and Giordano Nicoletti and Lorena Landuzzi and Arianna Palladini and Pier-Luigi Lollini and Patrizia Nanni",

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AU - De Giovanni, Carla

AU - Nicoletti, Giordano

AU - Landuzzi, Lorena

AU - Palladini, Arianna

AU - Lollini, Pier-Luigi

AU - Nanni, Patrizia

PY - 2019/11/27

Y1 - 2019/11/27

N2 - The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.

AB - The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor-host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.

KW - TS/A

KW - murine mammary cancer

KW - preclinical model

KW - gene therapy

KW - metastases

KW - immunotherapy

U2 - 10.3390/cancers11121889

DO - 10.3390/cancers11121889

M3 - Review article

C2 - 31783695

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JO - Cancers

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SN - 2072-6694

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ER -

Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

Abstract

Keywords

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