TY - JOUR
T1 - Biopsychosocial frailty and the risk of incident dementia
T2 - The Italian longitudinal study on aging
AU - Solfrizzi, Vincenzo
AU - Scafato, Emanuele
AU - Lozupone, Madia
AU - Seripa, Davide
AU - Schilardi, Andrea
AU - Custodero, Carlo
AU - Sardone, Rodolfo
AU - Galluzzo, Lucia
AU - Gandin, Claudia
AU - Baldereschi, Marzia
AU - Di Carlo, Antonio
AU - Inzitari, Domenico
AU - Giannelli, Gianluigi
AU - Daniele, Antonio
AU - Sabbà, Carlo
AU - Logroscino, Giancarlo
AU - Panza, Francesco
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Introduction: Frailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial domains/phenotypes. We operationalized a new biopsychosocial frailty (BF) construct, estimating its impact on the risk of incident dementia and its subtypes. Methods: In 2171 older individuals from the population-based Italian Longitudinal Study on Aging (ILSA), we identified by latent class procedures the BF construct as the physical frail status plus at least one of the two items of the 30-item Geriatric Depression Scale impaired (items 3/10). Results: Over a 3.5-year follow-up, participants with BF showed an increased risk of overall dementia (hazard ratio [HR]: 2.16, 95% confidence interval [CI]:1.07-4.37), particularly vascular dementia (VaD) (HR: 3.21, 95% CI: 1.05-9.75). Similarly, over a 7-year follow-up, an increased risk of overall dementia (HR: 1.84, 95% CI: 1.06-3.20), particularly VaD (HR: 2.53, 95% CI: 1.08-5.91), was also observed. Discussion: In a large cohort of Italian older individuals without cognitive impairment at baseline, a BF model was a short- and long-term predictor of overall dementia, particularly VaD.
AB - Introduction: Frailty is a critical intermediate status of the aging process including physical, cognitive, and psychosocial domains/phenotypes. We operationalized a new biopsychosocial frailty (BF) construct, estimating its impact on the risk of incident dementia and its subtypes. Methods: In 2171 older individuals from the population-based Italian Longitudinal Study on Aging (ILSA), we identified by latent class procedures the BF construct as the physical frail status plus at least one of the two items of the 30-item Geriatric Depression Scale impaired (items 3/10). Results: Over a 3.5-year follow-up, participants with BF showed an increased risk of overall dementia (hazard ratio [HR]: 2.16, 95% confidence interval [CI]:1.07-4.37), particularly vascular dementia (VaD) (HR: 3.21, 95% CI: 1.05-9.75). Similarly, over a 7-year follow-up, an increased risk of overall dementia (HR: 1.84, 95% CI: 1.06-3.20), particularly VaD (HR: 2.53, 95% CI: 1.08-5.91), was also observed. Discussion: In a large cohort of Italian older individuals without cognitive impairment at baseline, a BF model was a short- and long-term predictor of overall dementia, particularly VaD.
KW - Alzheimer's disease
KW - Cognitive frailty
KW - Dementia
KW - Frailty
KW - Lifestyle
KW - Physical frailty
KW - Social frailty
KW - Vascular dementia
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UR - http://www.scopus.com/inward/citedby.url?scp=85068139591&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2019.04.013
DO - 10.1016/j.jalz.2019.04.013
M3 - Article
AN - SCOPUS:85068139591
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
ER -