Bioresorbable phosphate scaffolds for bone regeneration

C. Vitale-Brovarone, E. Verné, F. Baino, G. Ciapetti, E. Leonardi, N. Baldini

Research output: Contribution to journalArticle

Abstract

In this work, a new bioresorbable phosphate glass (I-CEL2) was prepared in order to use it for the production of 3D-bioresorbable scaffold for bone regeneration. I-CEL2 was characterized to assess its thermal characteristics as well as its bioresorption rate in different medium such as distilled water, Tris-HCl and Simulated Body Fluid (SBF). 3D-macroporous scaffolds were prepared by mixing and pressing I-CEL2 powders and an organic phase and by treating the compact of powders at 550°C for 3 hours. The obtained scaffolds showed a very high porosity and a high resorption rate and are thus suitable candidates for a scaffold to be used as a temporary guide for bone regeneration. The initial response of human marrow stromal cells (hMSCs) has been tested on I-CEL2 surface to describe its biological potential.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalKey Engineering Materials
Volume361-363 I
Publication statusPublished - 2008

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Keywords

  • Bioresorbable scaffold
  • Bone grafting
  • Phosphate glass

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Ceramics and Composites

Cite this

Vitale-Brovarone, C., Verné, E., Baino, F., Ciapetti, G., Leonardi, E., & Baldini, N. (2008). Bioresorbable phosphate scaffolds for bone regeneration. Key Engineering Materials, 361-363 I, 241-244.