Bioresorbable Scaffolds for the Management of Coronary Bifurcation Lesions

Hiroyoshi Kawamoto, Neil Ruparelia, Akihito Tanaka, Alaide Chieffo, Azeem Latib, Antonio Colombo

Research output: Contribution to journalArticle

Abstract

The use of bioresorbable scaffolds (BRS) may be associated with benefits including restoration of endothelial function, positive vessel remodeling, and reduced risk for very late (stent) thrombosis compared with metallic stents by virtue of their complete absorption within 3 to 4 years of implantation. When treating bifurcation lesions, these advantages may be even more pronounced. The aim of this review is to summarize current experiences and technical considerations of bifurcation treatment with BRS. Because of the physical properties of current-generation BRS, there are concerns with regard to the efficacy and safety of this novel technology for the treatment of bifurcations, with the potential for increased rates of scaffold thrombosis and side-branch occlusions, and as a consequence, bifurcations have been excluded from the major BRS trials. Nevertheless, BRS have been used for this indication in clinical practice, as evidenced by "real-world" registries. Considering the potential limitations, specific technical considerations and modified bifurcation strategies should be used in an attempt to attenuate problems and achieve optimal procedural and clinical outcomes.

Original languageEnglish
Pages (from-to)989-1000
Number of pages12
JournalJACC: Cardiovascular Interventions
Volume9
Issue number10
DOIs
Publication statusPublished - May 23 2016

Keywords

  • bioresorbable scaffold
  • coronary bifurcation
  • percutaneous coronary intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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