Biosafety of Prions

Edoardo Bistaffa, Edoardo Bistaffa, Martina Rossi, Chiara M.G. De Luca, Chiara M.G. De Luca, Fabio Moda

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

© 2017 Elsevier Inc. Prions are the infectious agents that cause devastating and untreatable disorders known as Transmissible Spongiform Encephalopathies (TSEs). The pathologic events and the infectious nature of these transmissible agents are not completely understood yet. Due to the difficulties in inactivating prions, working with them requires specific recommendations and precautions. Moreover, with the advent of innovative technologies, such as the Protein Misfolding Cyclic Amplification (PMCA) and the Real Time Quaking-Induced Conversion (RT-QuIC), prions could be amplified in vitro and the infectious features of the amplified products need to be carefully assessed.
Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
Pages455-485
Number of pages31
Volume150
DOIs
Publication statusPublished - Jan 1 2017

Keywords

  • Biosafety
  • Decontamination
  • Infectivity
  • Prion diseases
  • Transmission

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