Biosensors for the Diagnosis of Celiac Disease: Current Status and Future Perspectives

Katharina Anne Scherf; Rachele Ciccocioppo; Miroslav Pohanka; Kvetoslava Rimarova; Radka Opatrilova; Luis Rodrigo; Peter Kruzliak

doi:10.1007/s12033-016-9940-3

Biosensors for the Diagnosis of Celiac Disease: Current Status and Future Perspectives

Katharina Anne Scherf, Rachele Ciccocioppo, Miroslav Pohanka, Kvetoslava Rimarova, Radka Opatrilova, Luis Rodrigo, Peter Kruzliak

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

Celiac disease (CD) is an autoimmune enteropathy initiated and sustained by the ingestion of gluten in genetically susceptible individuals. It is caused by a dysregulated immune response toward both dietary antigens, the gluten proteins of wheat, rye, and barley, and autoantigens, the enzyme tissue transglutaminase (TG2). The small intestine is the target organ. Although routine immunochemical protocols for a laboratory diagnosis of CD are available, faster, easier-to-use, and cheaper analytical devices for CD diagnosis are currently unavailable. This review focuses on biosensors, consisting of a physicochemical transducer and a bioreceptor, as promising analytical tools for diagnosis of CD and other diseases. Examples of recently developed biosensors as well as expectations for future lines of research and development in this field are presented.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Molecular Biotechnology
DOIs	https://doi.org/10.1007/s12033-016-9940-3
Publication status	Accepted/In press - Apr 29 2016

Keywords

Antibody
Biosensors
Celiac disease
Diagnosis
ELISA
Immunochemistry

ASJC Scopus subject areas

Biochemistry
Biotechnology
Molecular Biology
Bioengineering
Applied Microbiology and Biotechnology

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abstract = "Celiac disease (CD) is an autoimmune enteropathy initiated and sustained by the ingestion of gluten in genetically susceptible individuals. It is caused by a dysregulated immune response toward both dietary antigens, the gluten proteins of wheat, rye, and barley, and autoantigens, the enzyme tissue transglutaminase (TG2). The small intestine is the target organ. Although routine immunochemical protocols for a laboratory diagnosis of CD are available, faster, easier-to-use, and cheaper analytical devices for CD diagnosis are currently unavailable. This review focuses on biosensors, consisting of a physicochemical transducer and a bioreceptor, as promising analytical tools for diagnosis of CD and other diseases. Examples of recently developed biosensors as well as expectations for future lines of research and development in this field are presented.",

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AU - Scherf, Katharina Anne

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AU - Rimarova, Kvetoslava

AU - Opatrilova, Radka

AU - Rodrigo, Luis

AU - Kruzliak, Peter

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