Abstract
To date, two kinds of Granulocyte Colony-Stimulating Factors (G-CSF) have been approved for autologous peripheral blood hematopoietic stem cell (PBSCs) mobilization and posttransplant hematologic recovery after high-dose chemotherapy: filgrastim (originator and biosimilar) and lenograstim. Biosimilar filgrastim has been approved on the basis of comparable efficacy and safety in clinical studies where it has been used as chemotherapy-induced febrile neutropenia prophylaxis, but no specific pre-registration studies have been published in the transplant setting. Hence, there is still general skepticism about the role of biosimilar G-CSFs in this setting of patients. This review of biochemical, pre-clinical and clinical data suggests significant comparability of biosimilar filgrastim with both originator filgrastim and lenograstim in autologous PBSCs mobilization and post-autograft hematologic recovery.
Original language | English |
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Pages (from-to) | 2217-2229 |
Number of pages | 13 |
Journal | Current Medicinal Chemistry |
Volume | 23 |
Issue number | 21 |
DOIs | |
Publication status | Published - Jun 1 2016 |
Keywords
- Autologous stem cell transplant
- Biosimilar filgrastim
- Hematologic recovery
- Lenograstim
- Originator filgrastim
- Peripheral blood hematopoietic stem cell mobilization
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology