Biostatistics meets bioinformatics in integrating information from highdimensional heterogeneous genomic data: Two examples from rare genetic diseases and infectious diseases

Clelia Di Serio; Danilo Pellin; Alessandro Ambrosi; Ingrid Glad; Arnoldo Frigessi

doi:10.1007/978-3-642-35686-5_2

Biostatistics meets bioinformatics in integrating information from highdimensional heterogeneous genomic data: Two examples from rare genetic diseases and infectious diseases

Clelia Di Serio, Danilo Pellin, Alessandro Ambrosi, Ingrid Glad, Arnoldo Frigessi

IRCCS Ospedale San Raffaele

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Understanding genetic information to code and interpret disease phenotypes represents one major goal in modern biology. The challenge of integrating separate scientific vocabularies and insight is daunting because of the vastness and rapid evolution of the disciplines. New models and tools are needed to allow scientists to bridge knowledges, integrate concepts and information, and enable complex analysis. In this contribution we show two examples of datasets from Gene Therapy and Tubercolosis to highlight how integration between biostatistics and bioinformatics allows to gain information from the extremely large biogical databases produced with the new biotechnologies, such as Next Generation Sequencing (NGS) data.

Original language	English
Title of host publication	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages	10-20
Number of pages	11
Volume	7548 LNBI
DOIs	https://doi.org/10.1007/978-3-642-35686-5_2
Publication status	Published - 2012
Event	8th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2011 - Gargnano del Garda, Italy Duration: Jun 30 2011 → Jul 2 2011

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	7548 LNBI
ISSN (Print)	03029743
ISSN (Electronic)	16113349

Other

Other	8th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2011
Country	Italy
City	Gargnano del Garda
Period	6/30/11 → 7/2/11

Keywords

Comparative genomics
Gene therapy
Hotspots
MTB
NGS
sRNA

ASJC Scopus subject areas

Computer Science(all)
Theoretical Computer Science

Access to Document

10.1007/978-3-642-35686-5_2

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Di Serio, C., Pellin, D., Ambrosi, A., Glad, I., & Frigessi, A. (2012). Biostatistics meets bioinformatics in integrating information from highdimensional heterogeneous genomic data: Two examples from rare genetic diseases and infectious diseases. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 7548 LNBI, pp. 10-20). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7548 LNBI). https://doi.org/10.1007/978-3-642-35686-5_2

Biostatistics meets bioinformatics in integrating information from highdimensional heterogeneous genomic data : Two examples from rare genetic diseases and infectious diseases. / Di Serio, Clelia; Pellin, Danilo; Ambrosi, Alessandro; Glad, Ingrid; Frigessi, Arnoldo.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 7548 LNBI 2012. p. 10-20 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 7548 LNBI).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Di Serio, C, Pellin, D, Ambrosi, A, Glad, I & Frigessi, A 2012, Biostatistics meets bioinformatics in integrating information from highdimensional heterogeneous genomic data: Two examples from rare genetic diseases and infectious diseases. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 7548 LNBI, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 7548 LNBI, pp. 10-20, 8th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2011, Gargnano del Garda, Italy, 6/30/11. https://doi.org/10.1007/978-3-642-35686-5_2

Di Serio C, Pellin D, Ambrosi A, Glad I, Frigessi A. Biostatistics meets bioinformatics in integrating information from highdimensional heterogeneous genomic data: Two examples from rare genetic diseases and infectious diseases. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 7548 LNBI. 2012. p. 10-20. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-642-35686-5_2

Di Serio, Clelia ; Pellin, Danilo ; Ambrosi, Alessandro ; Glad, Ingrid ; Frigessi, Arnoldo. / Biostatistics meets bioinformatics in integrating information from highdimensional heterogeneous genomic data : Two examples from rare genetic diseases and infectious diseases. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 7548 LNBI 2012. pp. 10-20 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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