Biostatistics meets bioinformatics in integrating information from highdimensional heterogeneous genomic data: Two examples from rare genetic diseases and infectious diseases

Clelia Di Serio, Danilo Pellin, Alessandro Ambrosi, Ingrid Glad, Arnoldo Frigessi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Understanding genetic information to code and interpret disease phenotypes represents one major goal in modern biology. The challenge of integrating separate scientific vocabularies and insight is daunting because of the vastness and rapid evolution of the disciplines. New models and tools are needed to allow scientists to bridge knowledges, integrate concepts and information, and enable complex analysis. In this contribution we show two examples of datasets from Gene Therapy and Tubercolosis to highlight how integration between biostatistics and bioinformatics allows to gain information from the extremely large biogical databases produced with the new biotechnologies, such as Next Generation Sequencing (NGS) data.

Original languageEnglish
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages10-20
Number of pages11
Volume7548 LNBI
DOIs
Publication statusPublished - 2012
Event8th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2011 - Gargnano del Garda, Italy
Duration: Jun 30 2011Jul 2 2011

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7548 LNBI
ISSN (Print)03029743
ISSN (Electronic)16113349

Other

Other8th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2011
CountryItaly
CityGargnano del Garda
Period6/30/117/2/11

Keywords

  • Comparative genomics
  • Gene therapy
  • Hotspots
  • MTB
  • NGS
  • sRNA

ASJC Scopus subject areas

  • Computer Science(all)
  • Theoretical Computer Science

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