Biotechnologies and acute hepatic failure.

L. R. Fassati, S. Gatti, L. Caccamo, L. Latham, G. Rossi, P. Prato, G. Giammarinaro

Research output: Contribution to journalArticle

Abstract

Orthotopic liver transplantation survival for patients with acute liver failure is poor (50%). Mortality on the waiting list is high due to the lack of donors. For these reasons, the possibility of sustaining hepatic function by extra-corporeal liver perfusion must be considered. In this experimental research, two groups of pigs have been submitted to total de-vascularisation of the liver causing acute hepatic failure. In the first group (4 pigs) no extra-corporeal assistance has been used after total de-vascularisation. All pigs died between 16 and 33 hours after the acute hepatic failure was induced. In the second group (8 pigs) after complete hepatic de-vascularisation an extra-corporeal hepatic support by continuous allo-perfusion of isolated liver was performed using the Abouna-Costa extra-corporeal circuit. All pigs were observed during the acute hepatic failure which lasted from 6.30 to 7.30 hours. The data that were more positively influenced by the extra-corporeal assistance were ammonia and lactates that improved after the application of hepatic assistance.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
JournalFORUM - Trends in Experimental and Clinical Medicine
Volume9
Issue number3 Suppl 3
Publication statusPublished - Jul 1999

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Acute Liver Failure
Biotechnology
Liver
Swine
Lactates
Perfusion
Waiting Lists
Ammonia
Liver Transplantation
Tissue Donors
Survival
Mortality
Research

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Fassati, L. R., Gatti, S., Caccamo, L., Latham, L., Rossi, G., Prato, P., & Giammarinaro, G. (1999). Biotechnologies and acute hepatic failure. FORUM - Trends in Experimental and Clinical Medicine, 9(3 Suppl 3), 67-73.

Biotechnologies and acute hepatic failure. / Fassati, L. R.; Gatti, S.; Caccamo, L.; Latham, L.; Rossi, G.; Prato, P.; Giammarinaro, G.

In: FORUM - Trends in Experimental and Clinical Medicine, Vol. 9, No. 3 Suppl 3, 07.1999, p. 67-73.

Research output: Contribution to journalArticle

Fassati, LR, Gatti, S, Caccamo, L, Latham, L, Rossi, G, Prato, P & Giammarinaro, G 1999, 'Biotechnologies and acute hepatic failure.', FORUM - Trends in Experimental and Clinical Medicine, vol. 9, no. 3 Suppl 3, pp. 67-73.
Fassati, L. R. ; Gatti, S. ; Caccamo, L. ; Latham, L. ; Rossi, G. ; Prato, P. ; Giammarinaro, G. / Biotechnologies and acute hepatic failure. In: FORUM - Trends in Experimental and Clinical Medicine. 1999 ; Vol. 9, No. 3 Suppl 3. pp. 67-73.
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