Biphasic decay of cell-associated HIV-1 DNA in HIV-1-infected children on antiretroviral therapy

Anita De Rossi, A. Sarah Walker, Davide De Forni, Diana M. Gibb

Research output: Contribution to journalArticle

Abstract

Cell-associated HIV-1 DNA was quantified in 33 HIV-1-infected children followed for 96 weeks after the initiation of antiretroviral therapy. HIV-1 DNA decay was biphasic, being 10-fold more rapid during the first 4 weeks, and was inversely associated with the baseline plasma HIV-1-RNA level, but unrelated to HIV-1-RNA suppression. HIV-1 DNA decay per absolute CD4 cell number was lower than per 106 CD4 cells, suggesting an ongoing infection of newly produced CD4 cells, despite HIV-1 suppression in plasma.

Original languageEnglish
Pages (from-to)1961-1963
Number of pages3
JournalAIDS (London, England)
Volume16
Issue number14
DOIs
Publication statusPublished - Sep 27 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Biphasic decay of cell-associated HIV-1 DNA in HIV-1-infected children on antiretroviral therapy'. Together they form a unique fingerprint.

  • Cite this