Abstract
Bipolar disorder (BD) could represent a prodromal state of frontotemporal dementia (FTD). Two patients affected by lifelong BD with a progressive decline of cognitive functions, behavioral, and neurological signs, reached the early diagnosis of FTD before the age of 60. They were diagnosed as affected by primary progressive aphasia and FTD with parkinsonism, respectively. A diagnosis of FTD should therefore be taken into account, in case of unexpected cognitive and behavioral decline in patients with a long history of BD. Follow-up studies with genetic, neuropsychological, and neuroimaging markers of these BD/FTD patients could further explore some of the underlying association, opening new viable therapeutic options.
| Original language | English |
|---|---|
| Pages (from-to) | 973-979 |
| Number of pages | 7 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 55 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 2017 |
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Keywords
- behavioral decline
- Bipolar disorder
- cognitive impairment
- frontotemporal dementia
- parkinsonism
- primary progressive aphasia
ASJC Scopus subject areas
- Clinical Psychology
- Geriatrics and Gerontology
- Psychiatry and Mental health
Cite this
Bipolar disorder and frontotemporal dementia : An intriguing association. / Papazacharias, Apostolos; Lozupone, Madia; Barulli, Maria Rosaria; Capozzo, Rosa; Imbimbo, Bruno P.; Veneziani, Federica; De Blasi, Roberto; Nardini, Marcello; Seripa, Davide; Panza, Francesco; Logroscino, Giancarlo.
In: Journal of Alzheimer's Disease, Vol. 55, No. 3, 01.01.2017, p. 973-979.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bipolar disorder and frontotemporal dementia
T2 - An intriguing association
AU - Papazacharias, Apostolos
AU - Lozupone, Madia
AU - Barulli, Maria Rosaria
AU - Capozzo, Rosa
AU - Imbimbo, Bruno P.
AU - Veneziani, Federica
AU - De Blasi, Roberto
AU - Nardini, Marcello
AU - Seripa, Davide
AU - Panza, Francesco
AU - Logroscino, Giancarlo
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Bipolar disorder (BD) could represent a prodromal state of frontotemporal dementia (FTD). Two patients affected by lifelong BD with a progressive decline of cognitive functions, behavioral, and neurological signs, reached the early diagnosis of FTD before the age of 60. They were diagnosed as affected by primary progressive aphasia and FTD with parkinsonism, respectively. A diagnosis of FTD should therefore be taken into account, in case of unexpected cognitive and behavioral decline in patients with a long history of BD. Follow-up studies with genetic, neuropsychological, and neuroimaging markers of these BD/FTD patients could further explore some of the underlying association, opening new viable therapeutic options.
AB - Bipolar disorder (BD) could represent a prodromal state of frontotemporal dementia (FTD). Two patients affected by lifelong BD with a progressive decline of cognitive functions, behavioral, and neurological signs, reached the early diagnosis of FTD before the age of 60. They were diagnosed as affected by primary progressive aphasia and FTD with parkinsonism, respectively. A diagnosis of FTD should therefore be taken into account, in case of unexpected cognitive and behavioral decline in patients with a long history of BD. Follow-up studies with genetic, neuropsychological, and neuroimaging markers of these BD/FTD patients could further explore some of the underlying association, opening new viable therapeutic options.
KW - behavioral decline
KW - Bipolar disorder
KW - cognitive impairment
KW - frontotemporal dementia
KW - parkinsonism
KW - primary progressive aphasia
UR - http://www.scopus.com/inward/record.url?scp=85005951053&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85005951053&partnerID=8YFLogxK
U2 - 10.3233/JAD-160860
DO - 10.3233/JAD-160860
M3 - Article
AN - SCOPUS:85005951053
VL - 55
SP - 973
EP - 979
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 3
ER -