Bipolar disorder and frontotemporal dementia: An intriguing association

Apostolos Papazacharias; Madia Lozupone; Maria Rosaria Barulli; Rosa Capozzo; Bruno P. Imbimbo; Federica Veneziani; Roberto De Blasi; Marcello Nardini; Davide Seripa; Francesco Panza; Giancarlo Logroscino

doi:10.3233/JAD-160860

Bipolar disorder and frontotemporal dementia: An intriguing association

Apostolos Papazacharias, Madia Lozupone, Maria Rosaria Barulli, Rosa Capozzo, Bruno P. Imbimbo, Federica Veneziani, Roberto De Blasi, Marcello Nardini, Davide Seripa, Francesco Panza, Giancarlo Logroscino

IRCCS Casa Sollievo della Sofferenza

Research output: Contribution to journal › Article › peer-review

Abstract

Bipolar disorder (BD) could represent a prodromal state of frontotemporal dementia (FTD). Two patients affected by lifelong BD with a progressive decline of cognitive functions, behavioral, and neurological signs, reached the early diagnosis of FTD before the age of 60. They were diagnosed as affected by primary progressive aphasia and FTD with parkinsonism, respectively. A diagnosis of FTD should therefore be taken into account, in case of unexpected cognitive and behavioral decline in patients with a long history of BD. Follow-up studies with genetic, neuropsychological, and neuroimaging markers of these BD/FTD patients could further explore some of the underlying association, opening new viable therapeutic options.

Original language	English
Pages (from-to)	973-979
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	55
Issue number	3
DOIs	https://doi.org/10.3233/JAD-160860
Publication status	Published - Jan 1 2017

Keywords

behavioral decline
Bipolar disorder
cognitive impairment
frontotemporal dementia
parkinsonism
primary progressive aphasia

ASJC Scopus subject areas

Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/JAD-160860

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Bipolar disorder and frontotemporal dementia : An intriguing association. / Papazacharias, Apostolos; Lozupone, Madia; Barulli, Maria Rosaria; Capozzo, Rosa; Imbimbo, Bruno P.; Veneziani, Federica; De Blasi, Roberto; Nardini, Marcello; Seripa, Davide; Panza, Francesco; Logroscino, Giancarlo.

In: Journal of Alzheimer's Disease, Vol. 55, No. 3, 01.01.2017, p. 973-979.

Research output: Contribution to journal › Article › peer-review

Papazacharias, Apostolos ; Lozupone, Madia ; Barulli, Maria Rosaria ; Capozzo, Rosa ; Imbimbo, Bruno P. ; Veneziani, Federica ; De Blasi, Roberto ; Nardini, Marcello ; Seripa, Davide ; Panza, Francesco ; Logroscino, Giancarlo. / Bipolar disorder and frontotemporal dementia : An intriguing association. In: Journal of Alzheimer's Disease. 2017 ; Vol. 55, No. 3. pp. 973-979.

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