Bipolar disorder co-morbidity in children with attention deficit hyperactivity disorder

Renato Donfrancesco, Silvia Miano, Francesca Martines, Laura Ferrante, Maria Grazia Melegari, Gabriele Masi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The present study aimed at: (1) exploring rate and clinical features of superimposed bipolar disorder (BD) in Italian children with attention deficit hyperactivity disorder (ADHD), compared with a community sample, matched for age and gender; (2) exploring predictors of BD in ADHD children, by comparing ADHD children with or without superimposed BD. We studied 173 consecutive drug-naïve outpatients with ADHD (156 males and 17 females, mean age of 9.2 ± 2.3 years, age range 6-17.5. years), diagnosed with a clinical interview (Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL)); the control group consisted of a community-based sample of 100 healthy children. The rate of children with a diagnosis of BD was higher in the ADHD group (29/173, 16.7%) compared with controls (1/100, 1%), (P<0.001). Among the 29 children with ADHD + BD, 16 (55.2%) had a Bipolar Disorder-Not Otherwise Specified (BD-NOS), and 11 (37.9%) showed ultrarapid cycling. Compared with children with ADHD without BD, they showed a higher rate of combined sub-type (21/29, 72.4%), a higher score at ADHD-Rating Scale (total score and hyperactivity subscale), higher rates of major depression, oppositional defiant disorder and conduct disorder. In summary, children with ADHD present a higher risk for developing a superimposed BD. The identification of clinical features with an increased risk of BD can improve diagnosis, prognosis and treatments.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalPsychiatry Research
Volume186
Issue number2-3
DOIs
Publication statusPublished - Apr 30 2011

Fingerprint

Attention Deficit Disorder with Hyperactivity
Bipolar Disorder
Morbidity
Attention Deficit and Disruptive Behavior Disorders
Conduct Disorder
Mood Disorders
Schizophrenia
Appointments and Schedules
Outpatients
Interviews
Depression
Control Groups
Pharmaceutical Preparations

Keywords

  • ADHD
  • Adolescents
  • Bipolar disorder
  • Children
  • Co-morbidity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Bipolar disorder co-morbidity in children with attention deficit hyperactivity disorder. / Donfrancesco, Renato; Miano, Silvia; Martines, Francesca; Ferrante, Laura; Melegari, Maria Grazia; Masi, Gabriele.

In: Psychiatry Research, Vol. 186, No. 2-3, 30.04.2011, p. 333-337.

Research output: Contribution to journalArticle

Donfrancesco, R, Miano, S, Martines, F, Ferrante, L, Melegari, MG & Masi, G 2011, 'Bipolar disorder co-morbidity in children with attention deficit hyperactivity disorder', Psychiatry Research, vol. 186, no. 2-3, pp. 333-337. https://doi.org/10.1016/j.psychres.2010.07.008
Donfrancesco, Renato ; Miano, Silvia ; Martines, Francesca ; Ferrante, Laura ; Melegari, Maria Grazia ; Masi, Gabriele. / Bipolar disorder co-morbidity in children with attention deficit hyperactivity disorder. In: Psychiatry Research. 2011 ; Vol. 186, No. 2-3. pp. 333-337.
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