Bipolar Disorder With Psychotic Features and Ocular Toxoplasmosis: A Possible Pathogenetic Role of the Parasite?

Claudia Del Grande, Carlo Contini, Elisa Schiavi, Grazia Rutigliano, Martina Maritati, Silvia Seraceni, Barbara Pinto, Liliana Dell'Osso, Fabrizio Bruschi

Research output: Contribution to journalArticle

Abstract

Recent evidence suggests the involvement of Toxoplasma gondii infection in the emergence of psychotic and affective disorders. In this report, we describe the case of a young Brazilian woman affected by recurrent ocular toxoplasmosis and presenting with a manic episode with psychotic features in the context of a diagnosis of Bipolar Disorder (BD), type I. We observed a relationship between ocular manifestations and the clinical course of bipolar illness, confirmed by molecular analyses (nested-PCR), as well as by the high level of T. gondii specific IgG. This case report is the first showing the presence of circulating parasite DNA at the time of occurrence of psychiatric symptoms, thus providing further support for a possible role of the parasite in the pathogenesis of some cases of BD.

Original languageEnglish
Pages (from-to)192-195
Number of pages4
JournalJournal of Nervous and Mental Disease
Volume205
Issue number3
DOIs
Publication statusPublished - Mar 2017

Keywords

  • Journal Article

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    Del Grande, C., Contini, C., Schiavi, E., Rutigliano, G., Maritati, M., Seraceni, S., Pinto, B., Dell'Osso, L., & Bruschi, F. (2017). Bipolar Disorder With Psychotic Features and Ocular Toxoplasmosis: A Possible Pathogenetic Role of the Parasite? Journal of Nervous and Mental Disease, 205(3), 192-195. https://doi.org/10.1097/NMD.0000000000000496