Abstract
Nonmotor functions of the cerebellum are well known. Within this frame, the aim of this study was to compare psychiatric morbidity rates among patients affected by cerebellar diseases or Parkinson's disease (PD). Forty-seven patients (27 cerebellar and 20 PD) underwent a comprehensive psychiatric evaluation (psychopathological rating scales and the Structured Clinical Interview for DSM-IV-TR Axis I Disorders). Psychiatric disorders were slightly more frequent among cerebellar than among PD patients (89% vs. 75%; p = 0.21). Mood disorders were more frequent in the cerebellar than in the PD group (90% vs. 55%; p <0.01). Among those subjects with no psychiatric history prior to the onset of neurological disease, bipolar spectrum disorders were more frequent within the cerebellar group (p <0.01). These results confirm high rates of psychiatric disorders among cerebellar patients. The higher frequency of bipolar spectrum presentations found in the cerebellar group may suggest a specific involvement of cortico-cerebellar circuits in the pathophysiology of mood dysregulation.
| Original language | English |
|---|---|
| Pages (from-to) | 725-729 |
| Number of pages | 5 |
| Journal | Journal of Nervous and Mental Disease |
| Volume | 203 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 12 2015 |
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Keywords
- Bipolar disorder
- bipolar spectrum
- cerebellar lesions
- cerebellum
- Parkinson's disease
ASJC Scopus subject areas
- Psychiatry and Mental health
- Medicine(all)
Cite this
Bipolar Spectrum Disorders in Patients with Cerebellar Lesions : A Comparison with Parkinson's Disease. / Chiaie, Roberto Delle; Minichino, Amedeo; Salviati, Massimo; Fiorentini, Samantha; Tonini, Angelo; Bersani, Francesco Saverio; De Michele, Francesco; Caredda, Maria; Biondi, Massimo.
In: Journal of Nervous and Mental Disease, Vol. 203, No. 9, 12.09.2015, p. 725-729.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bipolar Spectrum Disorders in Patients with Cerebellar Lesions
T2 - A Comparison with Parkinson's Disease
AU - Chiaie, Roberto Delle
AU - Minichino, Amedeo
AU - Salviati, Massimo
AU - Fiorentini, Samantha
AU - Tonini, Angelo
AU - Bersani, Francesco Saverio
AU - De Michele, Francesco
AU - Caredda, Maria
AU - Biondi, Massimo
PY - 2015/9/12
Y1 - 2015/9/12
N2 - Nonmotor functions of the cerebellum are well known. Within this frame, the aim of this study was to compare psychiatric morbidity rates among patients affected by cerebellar diseases or Parkinson's disease (PD). Forty-seven patients (27 cerebellar and 20 PD) underwent a comprehensive psychiatric evaluation (psychopathological rating scales and the Structured Clinical Interview for DSM-IV-TR Axis I Disorders). Psychiatric disorders were slightly more frequent among cerebellar than among PD patients (89% vs. 75%; p = 0.21). Mood disorders were more frequent in the cerebellar than in the PD group (90% vs. 55%; p <0.01). Among those subjects with no psychiatric history prior to the onset of neurological disease, bipolar spectrum disorders were more frequent within the cerebellar group (p <0.01). These results confirm high rates of psychiatric disorders among cerebellar patients. The higher frequency of bipolar spectrum presentations found in the cerebellar group may suggest a specific involvement of cortico-cerebellar circuits in the pathophysiology of mood dysregulation.
AB - Nonmotor functions of the cerebellum are well known. Within this frame, the aim of this study was to compare psychiatric morbidity rates among patients affected by cerebellar diseases or Parkinson's disease (PD). Forty-seven patients (27 cerebellar and 20 PD) underwent a comprehensive psychiatric evaluation (psychopathological rating scales and the Structured Clinical Interview for DSM-IV-TR Axis I Disorders). Psychiatric disorders were slightly more frequent among cerebellar than among PD patients (89% vs. 75%; p = 0.21). Mood disorders were more frequent in the cerebellar than in the PD group (90% vs. 55%; p <0.01). Among those subjects with no psychiatric history prior to the onset of neurological disease, bipolar spectrum disorders were more frequent within the cerebellar group (p <0.01). These results confirm high rates of psychiatric disorders among cerebellar patients. The higher frequency of bipolar spectrum presentations found in the cerebellar group may suggest a specific involvement of cortico-cerebellar circuits in the pathophysiology of mood dysregulation.
KW - Bipolar disorder
KW - bipolar spectrum
KW - cerebellar lesions
KW - cerebellum
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=84941277126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941277126&partnerID=8YFLogxK
U2 - 10.1097/NMD.0000000000000359
DO - 10.1097/NMD.0000000000000359
M3 - Article
VL - 203
SP - 725
EP - 729
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
SN - 0022-3018
IS - 9
ER -