Birth size and gestational age in opposite-sex twins as compared to same-sex twins

An individual-based pooled analysis of 21 cohorts

Aline Jelenkovic, Reijo Sund, Yoshie Yokoyama, Yoon Mi Hur, Vilhelmina Ullemar, Catarina Almqvist, Patrik Ke Magnusson, Gonneke Willemsen, Meike Bartels, Catharina Em Van Beijsterveldt, Leonie H. Bogl, Kirsi H. Pietiläinen, Eero Vuoksimaa, Fuling Ji, Feng Ning, Zengchang Pang, Tracy L. Nelson, Keith E. Whitfield, Esther Rebato, Clare H. Llewellyn & 30 others Abigail Fisher, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D. Tarnoki, David L. Tarnoki, Syuichi Ooki, Maria A. Stazi, Corrado Fagnani, Sonia Brescianini, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Tessa L. Cutler, John L. Hopper, Robert F. Krueger, Matt McGue, Shandell Pahlen, Jeffrey M. Craig, Richard Saffery, Claire Ma Haworth, Robert Plomin, Ariel Knafo-Noam, David Mankuta, Lior Abramson, S. Alexandra Burt

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 twin cohorts in 15 countries derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), including 67,850 dizygotic twin individuals. Linear regression analyses showed that boys having a co-twin sister were, on average, 31 g (95% CI 18 to 45) heavier and 0.16 cm (95% CI 0.045 to 0.274) longer than those with a co-twin brother. In girls, birth size was not associated (5 g birth weight; 95% CI -8 to -18 and -0.089 cm birth length; 95% CI -0.202 to 0.025) with the sex of the co-twin. Gestational age was slightly shorter in boy-boy pairs than in boy-girl and girl-girl pairs. When birth size was standardized by gestational age, the magnitude of the associations was attenuated in boys, particularly for birth weight. In conclusion, boys with a co-twin sister are heavier and longer at birth than those with a co-twin brother. However, these differences are modest and partly explained by a longer gestation in the presence of a co-twin sister.

Original languageEnglish
Article number6300
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

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Gestational Age
Cohort Studies
Parturition
Siblings
Birth Weight
Dizygotic Twins
Linear Models
Regression Analysis
Pregnancy

Keywords

  • Birth size
  • gestational age

ASJC Scopus subject areas

  • General

Cite this

Birth size and gestational age in opposite-sex twins as compared to same-sex twins : An individual-based pooled analysis of 21 cohorts. / Jelenkovic, Aline; Sund, Reijo; Yokoyama, Yoshie; Hur, Yoon Mi; Ullemar, Vilhelmina; Almqvist, Catarina; Magnusson, Patrik Ke; Willemsen, Gonneke; Bartels, Meike; Beijsterveldt, Catharina Em Van; Bogl, Leonie H.; Pietiläinen, Kirsi H.; Vuoksimaa, Eero; Ji, Fuling; Ning, Feng; Pang, Zengchang; Nelson, Tracy L.; Whitfield, Keith E.; Rebato, Esther; Llewellyn, Clare H.; Fisher, Abigail; Bayasgalan, Gombojav; Narandalai, Danshiitsoodol; Bjerregaard-Andersen, Morten; Beck-Nielsen, Henning; Sodemann, Morten; Tarnoki, Adam D.; Tarnoki, David L.; Ooki, Syuichi; Stazi, Maria A.; Fagnani, Corrado; Brescianini, Sonia; Dubois, Lise; Boivin, Michel; Brendgen, Mara; Dionne, Ginette; Vitaro, Frank; Cutler, Tessa L.; Hopper, John L.; Krueger, Robert F.; McGue, Matt; Pahlen, Shandell; Craig, Jeffrey M.; Saffery, Richard; Haworth, Claire Ma; Plomin, Robert; Knafo-Noam, Ariel; Mankuta, David; Abramson, Lior; Burt, S. Alexandra.

In: Scientific Reports, Vol. 8, No. 1, 6300, 01.12.2018.

Research output: Contribution to journalArticle

Jelenkovic, A, Sund, R, Yokoyama, Y, Hur, YM, Ullemar, V, Almqvist, C, Magnusson, PK, Willemsen, G, Bartels, M, Beijsterveldt, CEV, Bogl, LH, Pietiläinen, KH, Vuoksimaa, E, Ji, F, Ning, F, Pang, Z, Nelson, TL, Whitfield, KE, Rebato, E, Llewellyn, CH, Fisher, A, Bayasgalan, G, Narandalai, D, Bjerregaard-Andersen, M, Beck-Nielsen, H, Sodemann, M, Tarnoki, AD, Tarnoki, DL, Ooki, S, Stazi, MA, Fagnani, C, Brescianini, S, Dubois, L, Boivin, M, Brendgen, M, Dionne, G, Vitaro, F, Cutler, TL, Hopper, JL, Krueger, RF, McGue, M, Pahlen, S, Craig, JM, Saffery, R, Haworth, CM, Plomin, R, Knafo-Noam, A, Mankuta, D, Abramson, L & Burt, SA 2018, 'Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts', Scientific Reports, vol. 8, no. 1, 6300. https://doi.org/10.1038/s41598-018-24634-2
Jelenkovic, Aline ; Sund, Reijo ; Yokoyama, Yoshie ; Hur, Yoon Mi ; Ullemar, Vilhelmina ; Almqvist, Catarina ; Magnusson, Patrik Ke ; Willemsen, Gonneke ; Bartels, Meike ; Beijsterveldt, Catharina Em Van ; Bogl, Leonie H. ; Pietiläinen, Kirsi H. ; Vuoksimaa, Eero ; Ji, Fuling ; Ning, Feng ; Pang, Zengchang ; Nelson, Tracy L. ; Whitfield, Keith E. ; Rebato, Esther ; Llewellyn, Clare H. ; Fisher, Abigail ; Bayasgalan, Gombojav ; Narandalai, Danshiitsoodol ; Bjerregaard-Andersen, Morten ; Beck-Nielsen, Henning ; Sodemann, Morten ; Tarnoki, Adam D. ; Tarnoki, David L. ; Ooki, Syuichi ; Stazi, Maria A. ; Fagnani, Corrado ; Brescianini, Sonia ; Dubois, Lise ; Boivin, Michel ; Brendgen, Mara ; Dionne, Ginette ; Vitaro, Frank ; Cutler, Tessa L. ; Hopper, John L. ; Krueger, Robert F. ; McGue, Matt ; Pahlen, Shandell ; Craig, Jeffrey M. ; Saffery, Richard ; Haworth, Claire Ma ; Plomin, Robert ; Knafo-Noam, Ariel ; Mankuta, David ; Abramson, Lior ; Burt, S. Alexandra. / Birth size and gestational age in opposite-sex twins as compared to same-sex twins : An individual-based pooled analysis of 21 cohorts. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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AU - Sund, Reijo

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AU - Hur, Yoon Mi

AU - Ullemar, Vilhelmina

AU - Almqvist, Catarina

AU - Magnusson, Patrik Ke

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AU - Bartels, Meike

AU - Beijsterveldt, Catharina Em Van

AU - Bogl, Leonie H.

AU - Pietiläinen, Kirsi H.

AU - Vuoksimaa, Eero

AU - Ji, Fuling

AU - Ning, Feng

AU - Pang, Zengchang

AU - Nelson, Tracy L.

AU - Whitfield, Keith E.

AU - Rebato, Esther

AU - Llewellyn, Clare H.

AU - Fisher, Abigail

AU - Bayasgalan, Gombojav

AU - Narandalai, Danshiitsoodol

AU - Bjerregaard-Andersen, Morten

AU - Beck-Nielsen, Henning

AU - Sodemann, Morten

AU - Tarnoki, Adam D.

AU - Tarnoki, David L.

AU - Ooki, Syuichi

AU - Stazi, Maria A.

AU - Fagnani, Corrado

AU - Brescianini, Sonia

AU - Dubois, Lise

AU - Boivin, Michel

AU - Brendgen, Mara

AU - Dionne, Ginette

AU - Vitaro, Frank

AU - Cutler, Tessa L.

AU - Hopper, John L.

AU - Krueger, Robert F.

AU - McGue, Matt

AU - Pahlen, Shandell

AU - Craig, Jeffrey M.

AU - Saffery, Richard

AU - Haworth, Claire Ma

AU - Plomin, Robert

AU - Knafo-Noam, Ariel

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