Abstract
Aims of the study were long term follow-up (FU) of bisphosphonates- associated osteonecrosis of the jaw (ONJ) in 35 cases observed by Gruppo Italiano Studio Linfomi (GISL) between 2002 and 2005 and the evaluation of its frequency in multiple myeloma patients over time. We asked the centres to up-date cases with ONJ, and to report new cases of ONJ diagnosed between 2006 and 2008. After a median FU of 31 months, 19 patients are alive, 13 died, mainly from progression of the primary disease, and three patients are lost to follow-up. Treatment was mainly conservative, however, nine patients underwent surgery. Overall improvement was reported in 13 patients, 11 stabilized, and eight patients progressed. One patient relapsed after dental procedure. ONJ impacted quality of life, causing pain and interfering with the ability to eat. Although the frequency of ONJ in myeloma patients in the period 2006-2008 was slightly increased (3.6% vs. 1.9% in 2002-2005), we confirm the rarity of the complication.
| Original language | English |
|---|---|
| Pages (from-to) | 850-852 |
| Number of pages | 3 |
| Journal | American Journal of Hematology |
| Volume | 84 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 2009 |
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ASJC Scopus subject areas
- Hematology
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Bisphosphonates associated osteonecrosis of the jaw : A long-term follow-up of a series of 35 cases observed by GISL and evaluation of its frequency over time. / Pozzi, Samantha; Marcheselli, Raffaella; Falorio, Simona; Masini, Luciano; Stelitano, Caterina; Falcone, Antonietta; Quarta, Giovanni; Ponchio, Luisa; Pitini, Vincenzo; Luminari, Stefano; Baldini, Luca.
In: American Journal of Hematology, Vol. 84, No. 12, 12.2009, p. 850-852.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bisphosphonates associated osteonecrosis of the jaw
T2 - A long-term follow-up of a series of 35 cases observed by GISL and evaluation of its frequency over time
AU - Pozzi, Samantha
AU - Marcheselli, Raffaella
AU - Falorio, Simona
AU - Masini, Luciano
AU - Stelitano, Caterina
AU - Falcone, Antonietta
AU - Quarta, Giovanni
AU - Ponchio, Luisa
AU - Pitini, Vincenzo
AU - Luminari, Stefano
AU - Baldini, Luca
PY - 2009/12
Y1 - 2009/12
N2 - Aims of the study were long term follow-up (FU) of bisphosphonates- associated osteonecrosis of the jaw (ONJ) in 35 cases observed by Gruppo Italiano Studio Linfomi (GISL) between 2002 and 2005 and the evaluation of its frequency in multiple myeloma patients over time. We asked the centres to up-date cases with ONJ, and to report new cases of ONJ diagnosed between 2006 and 2008. After a median FU of 31 months, 19 patients are alive, 13 died, mainly from progression of the primary disease, and three patients are lost to follow-up. Treatment was mainly conservative, however, nine patients underwent surgery. Overall improvement was reported in 13 patients, 11 stabilized, and eight patients progressed. One patient relapsed after dental procedure. ONJ impacted quality of life, causing pain and interfering with the ability to eat. Although the frequency of ONJ in myeloma patients in the period 2006-2008 was slightly increased (3.6% vs. 1.9% in 2002-2005), we confirm the rarity of the complication.
AB - Aims of the study were long term follow-up (FU) of bisphosphonates- associated osteonecrosis of the jaw (ONJ) in 35 cases observed by Gruppo Italiano Studio Linfomi (GISL) between 2002 and 2005 and the evaluation of its frequency in multiple myeloma patients over time. We asked the centres to up-date cases with ONJ, and to report new cases of ONJ diagnosed between 2006 and 2008. After a median FU of 31 months, 19 patients are alive, 13 died, mainly from progression of the primary disease, and three patients are lost to follow-up. Treatment was mainly conservative, however, nine patients underwent surgery. Overall improvement was reported in 13 patients, 11 stabilized, and eight patients progressed. One patient relapsed after dental procedure. ONJ impacted quality of life, causing pain and interfering with the ability to eat. Although the frequency of ONJ in myeloma patients in the period 2006-2008 was slightly increased (3.6% vs. 1.9% in 2002-2005), we confirm the rarity of the complication.
UR - http://www.scopus.com/inward/record.url?scp=73349097839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73349097839&partnerID=8YFLogxK
U2 - 10.1002/ajh.21553
DO - 10.1002/ajh.21553
M3 - Article
C2 - 19862827
AN - SCOPUS:73349097839
VL - 84
SP - 850
EP - 852
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 12
ER -