Bisphosphonates

Prevention of bone metastases in lung cancer

Lynn Decoster, Filippo De Marinis, Kostas Syrigos, Vera Hirsh, Kristiaan Nackaerts

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

In patients with lung cancer, bone is one of the most frequent sites of distant spread, with approximately 30% of patients developing skeletal metastases. About half of these patients will experience a skeletal-related event, the occurrence of which not only affects quality of life, but is also associated with poor prognosis. Bisphosphonates are currently the mainstay for treating bone metastases in patients with lung cancer, with proven beneficial effects on prevention and delay of skeletal complications. Their role in preventing the development of skeletal metastases, their anti-tumoral properties and their effect on survival remain to be elucidated. Other bone-targeted therapies are being investigated in phase II and III clinical trials and might expand the therapeutic arsenal in the near future.

Original languageEnglish
Title of host publicationRecent Results in Cancer Research
Pages93-108
Number of pages16
Volume192
DOIs
Publication statusPublished - 2012

Publication series

NameRecent Results in Cancer Research
Volume192
ISSN (Print)00800015

Fingerprint

Diphosphonates
Lung Neoplasms
Neoplasm Metastasis
Bone and Bones
Bone Neoplasms
Phase III Clinical Trials
Phase II Clinical Trials
Quality of Life
Survival
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Decoster, L., De Marinis, F., Syrigos, K., Hirsh, V., & Nackaerts, K. (2012). Bisphosphonates: Prevention of bone metastases in lung cancer. In Recent Results in Cancer Research (Vol. 192, pp. 93-108). (Recent Results in Cancer Research; Vol. 192). https://doi.org/10.1007/978-3-642-21892-7-4

Bisphosphonates : Prevention of bone metastases in lung cancer. / Decoster, Lynn; De Marinis, Filippo; Syrigos, Kostas; Hirsh, Vera; Nackaerts, Kristiaan.

Recent Results in Cancer Research. Vol. 192 2012. p. 93-108 (Recent Results in Cancer Research; Vol. 192).

Research output: Chapter in Book/Report/Conference proceedingChapter

Decoster, L, De Marinis, F, Syrigos, K, Hirsh, V & Nackaerts, K 2012, Bisphosphonates: Prevention of bone metastases in lung cancer. in Recent Results in Cancer Research. vol. 192, Recent Results in Cancer Research, vol. 192, pp. 93-108. https://doi.org/10.1007/978-3-642-21892-7-4
Decoster L, De Marinis F, Syrigos K, Hirsh V, Nackaerts K. Bisphosphonates: Prevention of bone metastases in lung cancer. In Recent Results in Cancer Research. Vol. 192. 2012. p. 93-108. (Recent Results in Cancer Research). https://doi.org/10.1007/978-3-642-21892-7-4
Decoster, Lynn ; De Marinis, Filippo ; Syrigos, Kostas ; Hirsh, Vera ; Nackaerts, Kristiaan. / Bisphosphonates : Prevention of bone metastases in lung cancer. Recent Results in Cancer Research. Vol. 192 2012. pp. 93-108 (Recent Results in Cancer Research).
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