TY - JOUR
T1 - Bisphosphonates Target B Cells to Enhance Humoral Immune Responses
AU - Tonti, Elena
AU - JiménezdeOya, Nereida
AU - Galliverti, Gabriele
AU - Moseman, E. Ashley
AU - DiLucia, Pietro
AU - Amabile, Angelo
AU - Sammicheli, Stefano
AU - DeGiovanni, Marco
AU - Sironi, Laura
AU - Chevrier, Nicolas
AU - Sitia, Giovanni
AU - Gennari, Luigi
AU - Guidotti, LucaG
AU - VonAndrian, UlrichH
AU - Iannacone, Matteo
PY - 2013
Y1 - 2013
N2 - Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens, and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4+ and γδ Tcells, neutrophils, or dendritic cells, and their effect does not rely on local macrophage depletion, Toll-like receptor signaling, or the inflammasome. Rather, bisphosphonates target directly B cells and enhance B cell expansion and antibody production upon antigen encounter. These data establish bisphosphonates as an additional class of adjuvants that boost humoral immune responses
AB - Bisphosphonates are a class of drugs that are widely used to inhibit loss of bone mass in patients. We show here that the administration of clinically relevant doses of bisphosphonates in mice increases antibody responses to live and inactive viruses, proteins, haptens, and existing commercial vaccine formulations. Bisphosphonates exert this adjuvant-like activity in the absence of CD4+ and γδ Tcells, neutrophils, or dendritic cells, and their effect does not rely on local macrophage depletion, Toll-like receptor signaling, or the inflammasome. Rather, bisphosphonates target directly B cells and enhance B cell expansion and antibody production upon antigen encounter. These data establish bisphosphonates as an additional class of adjuvants that boost humoral immune responses
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U2 - 10.1016/j.celrep.2013.09.004
DO - 10.1016/j.celrep.2013.09.004
M3 - Article
C2 - 24120862
AN - SCOPUS:84887018123
VL - 5
SP - 323
EP - 330
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 2
ER -